Author Affiliations: College of Nursing, The Ohio State University, Columbus (Drs Von Ah and Nolan); NewCourtland Center for Transitions and Health, University of Pennsylvania School of Nursing, Philadelphia (Dr Crouch); and The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus (Drs Arthur and Yang).
Cancer Nurs. 2023;46(2):E122-E128. doi: 10.1097/NCC.0000000000001083. Epub 2022 Dec 11.
Breast cancer survivors (BCSs) may have a greater risk for cardiovascular disease (congestive heart failure and hypertension), which in turn, can affect cognitive dysfunction, a frequent, bothersome, and potentially debilitating symptom.
The purpose of this study was to examine the relationship of cardiovascular disease on cognitive function in BCSs.
Baseline data from a double-blind randomized controlled trial for cognitive training of BCSs were examined. Early-stage BCS (stages I-IIIA) who were 21 years or older, completed adjuvant therapy (≥6 months), and reported cognitive concerns completed questionnaires and a brief neuropsychological assessment, including tests of memory, attention and working memory, speed of processing, and verbal fluency. Descriptive statistics, Pearson correlation coefficient, and separate linear regression models for each cognitive domain were conducted.
Forty-seven BCSs, who were on average 57.3 (SD, 8.1) years old, were 58% White, and had some college education (75%), completed the study. Furthermore, 44.7% of the BCS had cardiovascular disease (congestive heart failure or hypertension). In linear regression models, cardiovascular disease was significantly related to immediate and delayed memory and attention and working memory ( P < .01-.05).
Breast cancer survivors who have cardiovascular disease may also be at a greater risk for cognitive dysfunction post treatment. Results from this study inform both clinical practice and future research, specifically by examining the intersection between cancer, cardiovascular disease (cardiotoxicity), and cognition.
Nurses should be aware that BCSs with co-occurring cardiovascular disease are at a higher risk for cognitive dysfunction and work within the multidisciplinary team to optimize BCS health and function.
乳腺癌幸存者（BCS）可能有更大的心血管疾病（充血性心力衰竭和高血压）风险，这反过来又会影响认知功能，认知功能障碍是一种常见的、令人烦恼的、潜在的使人衰弱的症状。
本研究旨在探讨心血管疾病对 BCS 认知功能的影响。
对乳腺癌认知训练的双盲随机对照试验的基线数据进行了检查。年龄在 21 岁及以上、完成辅助治疗（≥6 个月）且报告有认知问题的早期 BCS（I 期-IIIA 期）患者完成了问卷调查和简短的神经心理评估，包括记忆、注意力和工作记忆、处理速度和言语流畅性测试。对每个认知领域进行描述性统计、皮尔逊相关系数和单独的线性回归模型。
47 名 BCS 平均年龄（标准差）为 57.3（8.1）岁，其中 58%为白人，接受过一些大学教育（75%），完成了研究。此外，44.7%的 BCS 患有心血管疾病（充血性心力衰竭或高血压）。在线性回归模型中，心血管疾病与即时和延迟记忆以及注意力和工作记忆显著相关（P<.01-.05）。
患有心血管疾病的乳腺癌幸存者在治疗后也可能面临更大的认知功能障碍风险。本研究的结果为临床实践和未来研究提供了信息，特别是通过检查癌症、心血管疾病（心脏毒性）和认知之间的交叉点。
护士应意识到同时患有心血管疾病的 BCS 认知功能障碍的风险较高，应与多学科团队合作，优化 BCS 的健康和功能。
