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碘造影剂诱导冠状动脉造影期间的 Kounis 综合征:危及生命的临床难题。

Iodinated contrast media induced Kounis syndrome during coronary angiogram: a life-threatening clinical dilemma.

机构信息

Internal Medicine Department, HFR Fribourg Hopital Cantonal, Villars-Sur-Glane, Fribourg, Switzerland

Cardiology Department, HFR Fribourg Hopital Cantonal, Villars-Sur-Glâne, Fribourg, Switzerland.

出版信息

BMJ Case Rep. 2022 Mar 30;15(3):e245047. doi: 10.1136/bcr-2021-245047.

Abstract

Kounis syndrome (KS) is a well-documented hypersensitivity vasospastic reaction induced by a variety of triggers. Clinical presentation ranges from non-specific symptoms such as dizziness and nausea to myocardial infarction. Many cases of KS were reported after the use of iodinated contrast media, mainly during radiological procedures. This report describes the case of a 46-year-old man developing coronary vasospasm and anaphylactic shock at the end of percutaneous coronary intervention. Occurrence of such pathology while performing coronary angiogram is a tricky situation for the invasive cardiologist. It requires recognising a rare syndrome and interrupting the procedure to avoid extra use of contrast media even in presence of severe coronary lesions due to vasospasm. Every interventionalist should be aware of such a presentation to recognise and react promptly when facing a potentially life-threatening clinical dilemma.

摘要

Kounis 综合征(KS)是一种由多种触发因素引起的已知的过敏血管痉挛反应。临床表现从非特异性症状(如头晕和恶心)到心肌梗死不等。许多 KS 病例是在使用碘造影剂后报告的,主要是在放射学程序期间。本报告描述了一名 46 岁男性在经皮冠状动脉介入治疗结束时发生冠状动脉痉挛和过敏性休克的病例。在进行冠状动脉造影时发生这种病理情况对介入心脏病学家来说是一种棘手的情况。它需要识别一种罕见的综合征,并中断该过程,以避免因血管痉挛导致严重的冠状动脉病变而额外使用造影剂。每个介入心脏病学家都应该意识到这种表现,以便在面临潜在危及生命的临床困境时能够及时识别并作出反应。

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本文引用的文献

1
Kounis Syndrome Leading to Cardiac Arrest After Iodinated Contrast Exposure.碘化造影剂暴露后引发心脏骤停的库尼斯综合征
JACC Case Rep. 2020 Apr 15;2(4):626-629. doi: 10.1016/j.jaccas.2019.12.044. eCollection 2020 Apr.
2
Contrast Media Induced Kounis Syndrome: A Case Report.造影剂诱发的库尼综合征:一例报告
Diagnostics (Basel). 2019 Oct 18;9(4):154. doi: 10.3390/diagnostics9040154.
7
Kounis syndrome: A concise review with focus on management.Kounis 综合征:重点关注治疗的简明综述。
Eur J Intern Med. 2016 May;30:7-10. doi: 10.1016/j.ejim.2015.12.004. Epub 2016 Jan 12.
9
Treatment of Kounis syndrome.库恩斯综合征的治疗。
Int J Cardiol. 2010 Sep 3;143(3):223-6. doi: 10.1016/j.ijcard.2010.02.040. Epub 2010 Mar 4.

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