依库珠单抗治疗胸腺瘤相关重症肌无力（MG）胸腺切除术后病情加重的疗效
[The efficacy of eculizumab against post-thymectomy exacerbations in thymoma associated myasthenia gravis (MG)].
作者信息
Takeuchi Eriko, Kajiyama Yuta, Ando Koshiro, Funaki Soichiro, Okuno Tatsusada, Shintani Yasushi, Mochizuki Hideki
机构信息
Department of Neurology, Osaka University Graduate School of Medicine.
Department of Neurology, Sakai City Medical Center.
出版信息
Rinsho Shinkeigaku. 2022 Apr 27;62(4):277-280. doi: 10.5692/clinicalneurol.cn-001682. Epub 2022 Mar 29.
We report a 62-year-old woman with thymoma associated myasthenia gravis (MG). She had significant dysphagia and was treated with corticosteroids, intravenous immunoglobulin (IVIG), immunoadsorption plasmapheresis (IAPP), and immunosuppressive drugs, and the extended thymectomy. Her symptoms gradually improved, but 3 weeks after thymectomy, her bulbar symptoms recurred. Although she was treated with repeated IVIG and IAPP, her symptom remained. Finally, after starting eculizumab did her symptoms go into complete remission. This case suggests the efficacy of anti-complement therapy for postoperative exacerbation of MG.
我们报告了一名62岁患有胸腺瘤相关重症肌无力（MG）的女性。她有严重的吞咽困难，接受了皮质类固醇、静脉注射免疫球蛋白（IVIG）、免疫吸附血浆置换（IAPP）、免疫抑制药物治疗以及扩大胸腺切除术。她的症状逐渐改善，但胸腺切除术后3周，她的延髓症状复发。尽管她接受了重复的IVIG和IAPP治疗，症状仍持续存在。最后，在开始使用依库珠单抗治疗后，她的症状完全缓解。该病例提示抗补体疗法对MG术后病情加重有效。
Zotero 插件