人源环状RNA hsa_circ_0007967通过miR-411-5p/MAML3轴促进胃癌增殖。

Zha Quanbin, Wu Xi, Zhang Jingxin, Xu Tingting, Shi YongKang, Sun Yayun, Fang Yuan, Gu Yunru, Ma Pei, Shu Yongqian, Tian Shengwang

Department of Oncology, Jintan Hospital, Jiangsu University, Changzhou, 213200, People's Republic of China.

Department of Oncology, the First Affifiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.

Cell Death Discov. 2022 Mar 30;8(1):144. doi: 10.1038/s41420-022-00954-1.

Circular RNAs are an important kind of noncoding RNAs and involved in cancerogenesis, but the specific mechanism between gastric cancer and circRNAs needs further study. Hsa_circ_0007967 was selected by RNA sequencing. Here, hsa_circ_0007967 was highly expressed in gastric cancer tissues than adjacent normal tissues. Overexpressing hsa_circ_0007967 promoted gastric cancer cell proliferation in vitro and in vivo, while suppression of hsa_circ_0007967 inhibited gastric cancer cell proliferation in vitro and in vivo. Mechanistically, hsa_circ_0007967 sponged miR-411-5p to increase MAML3 expression. Overall, hsa_circ_0007967 is a promising biomarker for gastric cancer diagnosis and a potential molecule for gastric cancer treatment.

环状RNA是一类重要的非编码RNA，参与肿瘤发生，但胃癌与环状RNA之间的具体机制仍需进一步研究。通过RNA测序筛选出了hsa_circ_0007967。在此，hsa_circ_0007967在胃癌组织中的表达高于相邻正常组织。过表达hsa_circ_0007967可促进胃癌细胞在体内外的增殖，而抑制hsa_circ_0007967则可抑制胃癌细胞在体内外的增殖。机制上，hsa_circ_0007967通过吸附miR-411-5p来增加MAML3的表达。总体而言，hsa_circ_0007967是一种有前景的胃癌诊断生物标志物，也是胃癌治疗的潜在分子。