Research Center for Human Movement Science, School of Physical Education, Shanxi University, Taiyuan, 030006, China.
Wuhan Institute of Bioengineering, Wuhan, 430415, China.
Sci Rep. 2022 Mar 30;12(1):5370. doi: 10.1038/s41598-022-09174-0.
The role of aerobic exercise in preventing and improving non-alcoholic fatty liver has been widely established. SRA is a long non-coding RNA, which has received increasing attention due to its important role in lipid metabolism. However, it is unclear whether aerobic exercise can prevent and treat hepatic lipid accumulation via SRA. The mice were randomly divided into four groups as follows, normal control group, normal aerobic exercise group, high-fat diet group (HFD), and high-fat diet plus aerobic exercise (8 weeks, 6 days/week, 18 m/min for 50 min, 6% slope) group (HAE). After 8 weeks, the mice in the HAE group showed significant improvement in hepatic steatosis. Body weight as well as blood TC, LDL-C, and liver TG levels were significantly lower in the HAE group than in the HFD group. Compared with the HFD group, the expression of SRA was markedly suppressed and the expression of ATGL was significantly increased in the HAE group. Additionally, the JNK/P38 signaling was inhibited, the pro-inflammatory factors were down-regulated, and the anti-inflammatory factor was increased. In addition to this, the same results were shown in experiments with overexpression of SRA. The results of this study provided new support for aerobic exercise to improve hepatic lipid metabolism via lncRNA.
有氧运动在预防和改善非酒精性脂肪肝方面的作用已得到广泛证实。SRA 是一种长链非编码 RNA，由于其在脂质代谢中的重要作用，受到越来越多的关注。然而，目前尚不清楚有氧运动是否可以通过 SRA 来预防和治疗肝脂质堆积。将小鼠随机分为四组：正常对照组、正常有氧运动组、高脂饮食组（HFD）和高脂饮食加有氧运动组（8 周，每周 6 天，18 m/min 运动 50 min，6%坡度）（HAE）。8 周后，HAE 组小鼠肝脂肪变性明显改善。与 HFD 组相比，HAE 组小鼠的体重以及血 TC、LDL-C 和肝 TG 水平显著降低。与 HFD 组相比，HAE 组 SRA 的表达明显被抑制，ATGL 的表达显著增加。此外，JNK/P38 信号通路被抑制，促炎因子下调，抗炎因子上调。此外，SRA 过表达的实验也得到了同样的结果。本研究为有氧运动通过 lncRNA 改善肝脂质代谢提供了新的支持。
