Sontag S J
Am J Gastroenterol. 1986 Nov;81(11):1021-8.
Naturally occurring PGs are considered important in maintaining the integrity of the gastrointestinal mucosa. Evidence indicates that synthetic analogs of PGs heal gastroduodenal ulcers in doses that suppress gastric acid. No consistent benefit of this class of drugs compared with already available conventional agents has been demonstrated in the treatment of duodenal or gastric ulcer disease. Nonantisecretory doses of PGs, by maintaining mucosal integrity and preventing ulcer recurrence, may eventually have a role in the treatment of ulcer disease. The potential of PGs to prevent gastroduodenal mucosal injury caused by nonsteroidal antiinflammatory drugs, alcohol, aspirin, and stress, if supported by the results of ongoing clinical trials, may be a major therapeutic advance for the treatment of peptic ulcer and related acid peptic diseases.
天然存在的前列腺素被认为对维持胃肠道黏膜的完整性很重要。有证据表明，前列腺素的合成类似物在抑制胃酸的剂量下可治愈胃十二指肠溃疡。在十二指肠或胃溃疡疾病的治疗中，与现有的传统药物相比，这类药物尚未显示出一致的益处。非抗分泌剂量的前列腺素通过维持黏膜完整性和预防溃疡复发，最终可能在溃疡疾病的治疗中发挥作用。如果正在进行的临床试验结果支持，前列腺素预防非甾体抗炎药、酒精、阿司匹林和应激引起的胃十二指肠黏膜损伤的潜力，可能是消化性溃疡和相关酸相关性疾病治疗的一项重大治疗进展。
