Morales W J, Lim D V, Walsh A F
Am J Obstet Gynecol. 1986 Nov;155(5):979-83. doi: 10.1016/0002-9378(86)90329-7.
A randomized 18-month study was conducted to determine the effect of intrapartum chemotherapy in the prevention of neonatal group B streptococcal disease. Twelve hundred seven indigent patients at term were screened weekly for group B streptococci antenatally with a rapid test based on coagglutination methods and at the time of admission in labor, 263 (22%) were confirmed to have colonization, 67 of which had heavy colonization. One hundred thirty-five of these mothers were randomized to a group treated with 1 gm of ampicillin intravenously every 6 hours until delivery. The remaining 128 mothers were not treated. None of the infants born to the treated mothers had colonization with group B streptococci at surface culture sites. Fifty-nine (46%) of the infants born to untreated mothers, including 24 of 30 (80%) from mothers with heavy colonization, had colonization. Ampicillin treatment administered during labor to pregnant patients with heavy colonization significantly reduced vertical transmission of group B streptococci.
一项为期18个月的随机研究旨在确定产时化疗在预防新生儿B族链球菌病中的作用。对1207名足月贫困患者进行每周一次的产前B族链球菌筛查，采用基于协同凝集法的快速检测，在分娩入院时，263名（22%）被确诊为有定植，其中67名有大量定植。这些母亲中有135名被随机分为一组，每6小时静脉注射1克氨苄西林直至分娩。其余128名母亲未接受治疗。接受治疗的母亲所生的婴儿在体表培养部位均未出现B族链球菌定植。未接受治疗的母亲所生的婴儿中有59名（46%）出现定植，其中包括30名有大量定植母亲所生婴儿中的24名（80%）。对有大量定植的孕妇在分娩期间给予氨苄西林治疗可显著降低B族链球菌的垂直传播。
