Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
GenProbio Srl, Parma, Italy.
Environ Microbiol. 2022 Sep;24(9):3912-3923. doi: 10.1111/1462-2920.15988. Epub 2022 Apr 7.
Fresh potable water is an indispensable drink which humans consume daily in substantial amounts. Nonetheless, very little is known about the composition of the microbial community inhabiting drinking water or its impact on our gut microbiota. In the current study, an exhaustive shotgun metagenomics analysis of the tap water microbiome highlighted the occurrence of a highly genetic biodiversity of the microbial communities residing in fresh water and the existence of a conserved core tap water microbiota largely represented by novel microbial species, representing microbial dark matter. Furthermore, genome reconstruction of this microbial dark matter from water samples unveiled homologous sequences present in the faecal microbiome of humans from various geographical locations. Accordingly, investigation of the faecal microbiota content of a subject that daily consumed tap water for 3 years provides proof for horizontal transmission and colonization of water bacteria in the human gut.
新鲜的饮用水是人类日常大量摄入的不可或缺的饮品。然而，人们对于饮用水中栖息的微生物群落的组成及其对我们肠道微生物组的影响知之甚少。在本研究中，对自来水微生物组进行了详尽的鸟枪法宏基因组学分析，结果突出显示了居住在淡水中的微生物群落具有高度遗传多样性，并且存在大量由新型微生物物种组成的保守核心自来水微生物组，代表了微生物暗物质。此外，从水样中对这种微生物暗物质进行基因组重建，揭示了来自不同地理位置的人类粪便微生物组中存在同源序列。因此，对一名连续 3 年每天饮用自来水的受试者的粪便微生物组内容进行调查，为水细菌在人类肠道中的水平传播和定植提供了证据。
