Chen Yuyan, Shi Tingchun, Yue Xiuyan
College of Automation, Hangzhou Dianzi University, Hangzhou 310018, Zhejiang, China.
Library of Hangzhou Dianzi University, Hangzhou 310018, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Mar 25;38(3):925-942. doi: 10.13345/j.cjb.210284.
Cartilage has poor self-recovery because of its characteristics of no blood vessels and high extracellular matrix. In clinical treatment, physical therapy or drug therapy is usually used for mild cartilage defects, and surgical treatment is needed for severe ones. In recent years, cartilage tissue engineering technology provides a new way for the treatment of cartilage defects. Compared with the traditional surgical treatment, cartilage tissue engineering technology has the advantages of small wound and good recovery. The application of microcarrier technology in the design of tissue engineering scaffolds further expands the function of scaffolds and promotes cartilage regeneration. This review summarized the main preparation methods and development of microcarrier technology in recent years. Subsequently, the properties and specific application scenarios of microcarriers with different materials and functions were introduced according to the materials and functions of microcarriers used in cartilage repair. Based on our research on osteochondral integrated layered scaffolds, we proposed an idea of optimizing the performance of layered scaffolds through microcarriers, which is expected to prepare bionic scaffolds that are more suitable for the structural characteristics of natural cartilage.
由于软骨无血管且细胞外基质含量高的特性，其自我修复能力较差。在临床治疗中，轻度软骨缺损通常采用物理治疗或药物治疗，严重缺损则需要手术治疗。近年来，软骨组织工程技术为软骨缺损的治疗提供了新途径。与传统手术治疗相比，软骨组织工程技术具有伤口小、恢复好的优点。微载体技术在组织工程支架设计中的应用进一步拓展了支架功能，促进了软骨再生。本文综述了近年来微载体技术的主要制备方法及发展情况。随后，根据用于软骨修复的微载体的材料和功能，介绍了不同材料和功能微载体的特性及具体应用场景。基于我们对骨软骨一体化分层支架的研究，提出了通过微载体优化分层支架性能的思路，有望制备出更适合天然软骨结构特征的仿生支架。
