Zhou Chen, Gong Ting, Chen Jingjing, Chen Tianjiao, Yang Jinling, Zhu Ping
NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Mar 25;38(3):1004-1024. doi: 10.13345/j.cjb.210587.
Triterpenoid saponins are widely used in medicine, health cares, cosmetics, food additives and agriculture because of their unique chemical properties and rich pharmacological activities. UDP-dependent glycosyltransferases (UGTs) are the key enzymes involved in triterpenoid saponin biosynthesis, and play important roles in the diversity of triterpenoid saponin structures and pharmacological activities. This review summarized the UGTs involved in plant triterpenoid saponin biosynthesis based on the sources of UGTs and the types of receptors. Moreover, the application of UGTs in heterologous biosynthesis of triterpenoid saponins based on synthetic biology was also discussed.
三萜皂苷因其独特的化学性质和丰富的药理活性而广泛应用于医药、保健品、化妆品、食品添加剂和农业等领域。尿苷二磷酸依赖性糖基转移酶（UGTs）是参与三萜皂苷生物合成的关键酶，在三萜皂苷结构多样性和药理活性方面发挥着重要作用。本文基于UGTs的来源和受体类型，综述了参与植物三萜皂苷生物合成的UGTs。此外，还讨论了基于合成生物学的UGTs在三萜皂苷异源生物合成中的应用。
