Mishra Rakesh, Konar Subhas K, Shrivastava Adesh, Chouksey Pradeep, Raj Sumit, Agrawal Amit
Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Indian J Endocrinol Metab. 2021 Nov-Dec;25(6):493-506. doi: 10.4103/ijem.ijem_338_21. Epub 2022 Feb 17.
Cabergoline has long been used in the medical management of prolactin-secreting pituitary adenomas. However, there is contradicting and inadequate evidence on the efficacy of cabergoline in achieving radiological and biochemical remission in prolactinoma. This article presents scoping review of evidence in cabergoline achieving radiological and biochemical remission in cases of prolactinoma. We have used a recommended scoping review methodology to map and summarize existing research evidence and identify knowledge gaps. The review process was conducted according to the PRISMA-ScR guidelines (Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews). The selection of studies was based on the criteria defined. Essential information such as reference details, study characteristics, topics of interest, main findings, and the study author's conclusion are presented in text and tables. With the study selection process, eight publications were finally included-one systematic review and meta-analysis, one RCT, and six primary studies. Cabergoline is effective in achieving biochemical and radiological remission in cases of prolactinoma. We identified several knowledge gaps with the scoping review and directions for future studies. Future studies, including randomized studies, will help address challenging questions associated with the management of prolactinoma.
卡麦角林长期以来一直用于分泌催乳素的垂体腺瘤的医学治疗。然而，关于卡麦角林在催乳素瘤中实现影像学和生化缓解的疗效，存在相互矛盾且不充分的证据。本文对卡麦角林在催乳素瘤病例中实现影像学和生化缓解的证据进行了范围综述。我们采用了推荐的范围综述方法来梳理和总结现有研究证据，并识别知识空白。综述过程按照PRISMA-ScR指南（系统评价和Meta分析扩展的范围综述的首选报告项目）进行。研究的选择基于所定义的标准。参考文献细节、研究特征、感兴趣的主题、主要发现以及研究作者的结论等基本信息在正文和表格中呈现。通过研究选择过程，最终纳入了八篇出版物——一篇系统评价和Meta分析、一篇随机对照试验和六篇原发性研究。卡麦角林在催乳素瘤病例中实现生化和影像学缓解方面是有效的。我们通过范围综述确定了几个知识空白以及未来研究的方向。未来的研究，包括随机研究，将有助于解决与催乳素瘤管理相关的具有挑战性的问题。
