血清 IGFBP-2 和 CTGF 水平升高与皮肌炎患者的疾病活动度相关。

Elevated Serum IGFBP-2 and CTGF Levels Are Associated with Disease Activity in Patients with Dermatomyositis.

机构信息

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.

Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu 610041, China.

出版信息

Dis Markers. 2022 Mar 20;2022:9223883. doi: 10.1155/2022/9223883. eCollection 2022.

DOI:10.1155/2022/9223883

PMID:35356065

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8958080/

Abstract

BACKGROUND

Insulin-like growth factor-binding proteins (IGFBPs) and connective tissue growth factor (CTGF) participate in angiogenesis. Dermatomyositis (DM) is characterized by microvasculopathy-derived skin lesions. Here, we investigated the clinical significance of serum IGFBP and CTGF levels in DM patients.

METHODS

In this study, 65 DM patients and 30 healthy controls were enrolled. Serum IGFBP and CTGF levels were examined by ELISA, and their correlation with clinical and laboratory findings was analyzed by Spearman's correlation.

RESULTS

Serum IGFBP-2, IGFBP-4, and CTGF levels were higher in DM patients than in healthy controls (median (quartile): 258.9 (176.4-326.1) ng/mL vs. 167.7 (116.1-209.4) ng/mL, < 0.0001; 450.4 (327.3-631.8) ng/mL vs. 392.2 (339.0-480.2) ng/mL, = 0.04; and 45.71 (38.54-57.45) ng/mL vs. 35.52 (30.23-41.52) ng/mL, = 0.001, respectively). IGFBP-2 and CTGF levels were positively correlated with cutaneous ( = 0.257, = 0.040 and = 0.427, = 0.015, respectively) and global ( = 0.380, = 0.002 and = 0.292, = 0.019, respectively) disease activity in DM patients.

CONCLUSION

Serum IGFBP-2 and CTGF levels were increased in patients with DM and correlated with cutaneous and global disease activity.

摘要

背景

胰岛素样生长因子结合蛋白（IGFBPs）和结缔组织生长因子（CTGF）参与血管生成。皮肌炎（DM）的特征是微血管病源性皮肤损伤。在此，我们研究了 DM 患者血清 IGFBP 和 CTGF 水平的临床意义。

方法

本研究纳入了 65 例 DM 患者和 30 例健康对照者。采用 ELISA 检测血清 IGFBP 和 CTGF 水平，并采用 Spearman 相关分析分析其与临床和实验室发现的相关性。

结果

DM 患者的血清 IGFBP-2、IGFBP-4 和 CTGF 水平高于健康对照组（中位数（四分位数）：258.9（176.4-326.1）ng/mL 比 167.7（116.1-209.4）ng/mL，＜0.0001；450.4（327.3-631.8）ng/mL 比 392.2（339.0-480.2）ng/mL， = 0.04；和 45.71（38.54-57.45）ng/mL 比 35.52（30.23-41.52）ng/mL， = 0.001）。IGFBP-2 和 CTGF 水平与皮肤（ = 0.257， = 0.040 和 = 0.427， = 0.015，分别）和整体（ = 0.380， = 0.002 和 = 0.292， = 0.019，分别）疾病活动在 DM 患者中呈正相关。