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一例常见可变免疫缺陷患者的致命性鼻出血：病例报告及文献复习

Fatal epistaxis in a case of common variable immunodeficiency: A case report and review of the literature.

作者信息

Barber Lucy, Jordan Anthony, Douglas Richard

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery Auckland City Hospital Auckland New Zealand.

Department of General Medicine Clinical Immunology and Allergy Auckland City Hospital Auckland New Zealand.

出版信息

Clin Case Rep. 2022 Mar 23;10(3):e05602. doi: 10.1002/ccr3.5602. eCollection 2022 Mar.

DOI:10.1002/ccr3.5602
PMID:35356174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8943115/
Abstract

Common variable immunodeficiency (CVID) is a primary immunodeficiency disease. We present a case of a patient with CVID complicated by rhinosinusitis with granulomatous inflammation. Treatment for this patient was challenging with regards recognition of the granulomatous manifestation as well as treatment in the setting immunodeficiency and was ultimately unsuccessful.

摘要

普通可变免疫缺陷（CVID）是一种原发性免疫缺陷疾病。我们报告一例患有CVID并伴有肉芽肿性炎症的鼻窦炎患者。对于该患者的治疗，在识别肉芽肿表现以及在免疫缺陷背景下进行治疗方面都具有挑战性，最终治疗未成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/a73d52fb056f/CCR3-10-e05602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/67a655fc5027/CCR3-10-e05602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/7f4974286390/CCR3-10-e05602-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/a73d52fb056f/CCR3-10-e05602-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/67a655fc5027/CCR3-10-e05602-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/7f4974286390/CCR3-10-e05602-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f23f/8943115/a73d52fb056f/CCR3-10-e05602-g001.jpg

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本文引用的文献

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World Neurosurg. 2017 Dec;108:985.e13-985.e14. doi: 10.1016/j.wneu.2017.09.006. Epub 2017 Sep 30.
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Immune deficiency in chronic rhinosinusitis: screening and treatment.慢性鼻-鼻窦炎中的免疫缺陷：筛查与治疗
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Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of the literature and meta-analysis.
慢性鼻-鼻窦炎患者的免疫球蛋白缺陷：文献系统评价和荟萃分析。
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The variable in common variable immunodeficiency: a disease of complex phenotypes.常见可变免疫缺陷中的变量：一种具有复杂表型的疾病。
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Antibody deficiency in chronic rhinosinusitis: epidemiology and burden of illness.慢性鼻-鼻窦炎中的抗体缺陷：流行病学和疾病负担。
Am J Rhinol Allergy. 2013 Jan;27(1):34-8. doi: 10.2500/ajra.2013.27.3831.
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Morbidity and mortality in common variable immune deficiency over 4 decades.四十余年来常见可变免疫缺陷的发病率和死亡率。
Blood. 2012 Feb 16;119(7):1650-7. doi: 10.1182/blood-2011-09-377945. Epub 2011 Dec 16.
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Granulomatous disease in common variable immunodeficiency.常见可变免疫缺陷中的肉芽肿病
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Autoimmune manifestations in primary immune deficiencies.原发性免疫缺陷中的自身免疫表现。
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