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双侧声带小叶状毛细血管瘤在一名慢性吸烟者中酷似声门癌。

Bilateral Vocal Fold Lobular Capillary Hemangioma Mimicking Glottic Carcinoma in a Chronic Smoker.

作者信息

Zulkefli Nur Af'Idah Mohd, Baki Marina Mat

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

出版信息

Oman Med J. 2022 Mar 22;37(2):e355. doi: 10.5001/omj.2021.49. eCollection 2022 Mar.

DOI:10.5001/omj.2021.49
PMID:35356375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8941334/
Abstract

Laryngeal hemangioma is a rare benign tumor of the larynx with predilection for a supraglottal subsite. Common presentations include hoarseness, dyspnea, and dysphagia, with a typical appearance of a reddish-purplish mass. A capillary form of the tumor, lobular capillary hemangioma (LCH) is extremely rare in adults and is predominantly unilateral. Diagnosis is made histologically by the distinct lobular growth pattern of capillary proliferation. Here, we report a 50-year-old male chronic smoker who presented with 3-month history of progressive hoarseness, dry cough, and intermittent dyspnea. Flexible endoscopy of the larynx showed irregular pinkish-white masses on the middle third of the bilateral vocal folds. The provisional diagnosis of glottic carcinoma was ruled out by histopathology, and the final diagnosis was bilateral glottic LCH, making it the first recorded case of this condition in literature. The patient underwent endolaryngeal microsurgery with subepithelial excision, a procedure that can be both diagnostic and therapeutic for this rare tumor.

摘要

喉血管瘤是一种罕见的喉部良性肿瘤,好发于声门上亚部位。常见表现包括声音嘶哑、呼吸困难和吞咽困难,典型表现为红紫色肿块。肿瘤的一种毛细血管形式,即小叶状毛细血管血管瘤(LCH)在成人中极为罕见,且主要为单侧性。通过毛细血管增生独特的小叶状生长模式进行组织学诊断。在此,我们报告一名50岁男性慢性吸烟者,有3个月进行性声音嘶哑、干咳和间歇性呼吸困难病史。喉镜检查显示双侧声带中三分之一处有不规则粉白色肿块。组织病理学排除了声门癌的初步诊断,最终诊断为双侧声门LCH,这使其成为文献中该病症的首例记录病例。患者接受了喉内显微手术及上皮下切除术,该手术对这种罕见肿瘤兼具诊断和治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def0/8941334/ace00b2f7796/OMJ-37-02-1900187-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def0/8941334/03fd55c205f6/OMJ-37-02-1900187-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def0/8941334/ace00b2f7796/OMJ-37-02-1900187-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def0/8941334/03fd55c205f6/OMJ-37-02-1900187-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def0/8941334/ace00b2f7796/OMJ-37-02-1900187-f2.jpg

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本文引用的文献

1
Endonasal Endoscopic Complete Excision of Unilateral Nasal Hemangioma in a Child: Case Report and Technical Note.儿童单侧鼻腔血管瘤的鼻内镜下完整切除:病例报告及技术要点
Oman Med J. 2019 Mar;34(2):156-159. doi: 10.5001/omj.2019.28.
2
Spectrum of Sinonasal Tumors: A 10-year Experience at a Tertiary Care Hospital in North India.鼻窦肿瘤谱:印度北部一家三级医疗医院的10年经验
Oman Med J. 2015 Nov;30(6):435-40. doi: 10.5001/omj.2015.86.
3
Lobular capillary hemangioma of the trachea.气管小叶状毛细血管瘤
Arch Iran Med. 2015 Feb;18(2):127-9.
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Adult laryngeal haemangioma; a rare entity.成人喉血管瘤;一种罕见的病症。
J Pak Med Assoc. 2012 Feb;62(2):173-4.
5
Vocal cord hemangioma.声带血管瘤
Med J Malaysia. 2008 Dec;63(5):419-20.
6
Lobular capillary hemangioma of the neonatal larynx.新生儿喉部小叶状毛细血管瘤
Arch Otolaryngol Head Neck Surg. 2008 Mar;134(3):272-7. doi: 10.1001/archoto.2007.47.
7
Current opinion in diagnosis and treatment of laryngeal carcinoma.喉癌诊断与治疗的当前观点
Cancer Treat Rev. 2006 Nov;32(7):504-15. doi: 10.1016/j.ctrv.2006.07.002. Epub 2006 Aug 22.
8
Cavernous hemangioma of the left vocal cord.左侧声带海绵状血管瘤
Eur Arch Otorhinolaryngol. 2004 Jul;261(6):310-1. doi: 10.1007/s00405-003-0695-7. Epub 2003 Oct 10.
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Fungal infection of the epiglottis simulating a clinical malignancy.模拟临床恶性肿瘤的会厌真菌感染。
Arch Otolaryngol Head Neck Surg. 2003 Jan;129(1):124-6. doi: 10.1001/archotol.129.1.124.
10
The dysphonia severity index: an objective measure of vocal quality based on a multiparameter approach.发音障碍严重程度指数:一种基于多参数方法的嗓音质量客观测量指标。
J Speech Lang Hear Res. 2000 Jun;43(3):796-809. doi: 10.1044/jslhr.4303.796.