坏死性葡萄膜黑色素瘤酷似眼眶蜂窝织炎：综述
Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review.
作者信息
Abdel-Aty Ahmad, Linderman Wendy L, Kombo Ninani, Sinard John, Pointdujour-Lim Renelle
机构信息
Yale University School of Medicine, New Haven, Connecticut, USA.
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Ocul Oncol Pathol. 2022 Feb;8(1):1-8. doi: 10.1159/000515558. Epub 2021 Nov 23.
BACKGROUND
Uveal melanoma is the most common primary intraocular malignancy in adults, often resulting in painless vision loss. We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and tabulation of reported cases.
SUMMARY
Our review found 44 published reports of spontaneously necrotic uveal melanoma involving 55 patients. Of these reports, 26 patients (47%) presented with orbital cellulitis. Presenting symptoms of necrotic uveal melanoma with orbital cellulitis included proptosis (82.8%), pain (80.7%), vision loss (61.5%), and restricted extraocular movements (46.2%).
KEY MESSAGES
Uveal melanoma can rarely mimic orbital cellulitis. Autoinfarction and tumor necrosis causes secondary orbital inflammation. Intraocular malignancy must remain in the differential for patients with orbital inflammation and vision loss.
背景
葡萄膜黑色素瘤是成人最常见的原发性眼内恶性肿瘤，常导致无痛性视力丧失。我们报告一例坏死性葡萄膜黑色素瘤表现为类似眼眶蜂窝织炎的眼眶炎症，并对文献进行全面综述及已报道病例列表。
总结
我们的综述发现44篇关于自发性坏死性葡萄膜黑色素瘤的已发表报告，涉及55例患者。在这些报告中，26例患者（47%）表现为眼眶蜂窝织炎。坏死性葡萄膜黑色素瘤伴眼眶蜂窝织炎的表现症状包括眼球突出（82.8%）、疼痛（80.7%）、视力丧失（61.5%）和眼球运动受限（46.2%）。
关键信息
葡萄膜黑色素瘤很少能模仿眼眶蜂窝织炎。自梗死和肿瘤坏死会引起继发性眼眶炎症。对于眼眶炎症和视力丧失的患者，眼内恶性肿瘤必须纳入鉴别诊断。
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