比较格列本脲、二甲双胍和胰岛素治疗妊娠期糖尿病的疗效和安全性：系统评价和荟萃分析方案。
Comparative efficacy and safety of glyburide, metformin, and insulin in treatment of gestational diabetes mellitus: A protocol for systematic review and meta-analysis.
机构信息
Department of Health Management Center, Ningbo Women and Children's Hospital, Zhejiang, China,Department of Education, Ningbo Women and Children's Hospital, Zhejiang, China,Department of Internal Medicine, Ningbo Women and Children's Hospital, Zhejiang, China.
出版信息
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029090.
BACKGROUND
The increased prevalence of gestational diabetes mellitus (GDM) has caused a huge societal economic and healthy burden at both the population and individual levels. We aimed to assess the comparative efficiency and safety of the use of glyburide, metformin, and insulin in GDM from a protocol for systematic review and meta-analysis.
METHODS
Two individual researchers conducted the platform searches on the PubMed, Cochrane Library, and Embase databases from inception to February 2022. Literature retrieving was carried out through a combined searching of subject terms ("MeSH" on PubMed and "Emtree" on "Embase") and free terms on the platforms of PubMed and Embase, and through keywords searching on platform of Cochrane Library. Systematic review and meta-analysis of the data will be performed in STATA13.0 software according to the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two authors independently performed the literature searching, data extraction, and quality evaluation. Risk of bias was assessed using the Cochrane Risk of Bias Tool for randomized controlled trials.
RESULTS
The results will be submitted to a peer-reviewed journal.
CONCLUSION
This meta-analysis will provide a comprehensive analysis and synthesis that can be used as an evidence map to inform practitioners and policy makers about the effectiveness of glyburide, metformin, and insulin for patients with GDM.
背景
妊娠期糖尿病（GDM）的患病率不断上升，给个人和人群层面带来了巨大的社会经济和健康负担。本研究旨在从系统评价和荟萃分析方案中评估格列本脲、二甲双胍和胰岛素在 GDM 中的比较效果和安全性。
方法
两名研究人员于 2022 年 2 月前在 PubMed、Cochrane Library 和 Embase 数据库中进行了平台检索。文献检索是通过在 PubMed 上使用主题词（“MeSH”）和 Embase 上的“Emtree”以及在 PubMed 和 Embase 平台上的自由词，以及在 Cochrane Library 平台上的关键词搜索相结合进行的。根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，将在 STATA13.0 软件中对数据进行系统评价和荟萃分析。两名作者独立进行文献检索、数据提取和质量评估。使用 Cochrane 随机对照试验偏倚风险工具评估偏倚风险。
结果
研究结果将提交给同行评议期刊。
结论
这项荟萃分析将提供全面的分析和综合，可作为证据图，为从业者和决策者提供有关格列本脲、二甲双胍和胰岛素治疗 GDM 患者的有效性的信息。
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