Department of Laboratory Medicine, Children's Hospital of Soochow University,Suzhou, China,Department of Laboratory Medicine, The First Affiliated Hospitalof Nanjing Medical University, Nanjing, China,National Key Clinical Departmentof Laboratory Medicine, Nanjing, China.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029101.
The clinical use of the cardiac troponin T (cTnT) assay was limited to the adult population in the diagnosis and prognosis of myocardial injury. However, emerging studies indicated its significant value in the assessment of pediatric cardiology, and it has been routinely measured in most hospitals. Our study investigated the normative values of cTnT in Chinese children and reported the age-specific 99th percentile cut-off for them.A total of 1280 apparently healthy Chinese children were enrolled in our study. Serum levels of cTnT were analyzed on the Roche Elecsys Troponin T Gen 5 STAT assay. According to the Clinical and Laboratory Standards Institute C28-A3 guideline, the 99th percentile upper reference limits (URLs) with 90% confidence intervals (CIs) were calculated in different age subgroups.The 99th percentile URL was 38 (90%CI: 37.0-51.0) ng/L for 1 to <4months old, 26 (90%CI: 25.2-28.5) ng/L for 4 to ≤ 12months old, and 12 (90%CI: 11.1-12.9) ng/L for 1 to 18 years old, respectively. For subjects aged from 1 to 18years, boys had slightly higher cTnT levels than girls (P = .003), while our assay could not measure low cTnT concentrations (≥the limit of detection) in 50% girls.Our study provided age-specific URLs of cTnT for Chinese children, with the 5th generation cTnT assay from Roche Diagnostics. It had significant clinical implications in the interpretation and use of test results for pediatric cardiology.
心肌肌钙蛋白 T（cTnT）检测在心肌损伤的诊断和预后方面的临床应用仅限于成人。然而，新的研究表明其在儿科心脏病学评估中具有重要价值，并且在大多数医院中已常规测量。我们的研究调查了 cTnT 在中国儿童中的正常值，并报告了适用于他们的年龄特异性第 99 百分位截断值。
我们的研究共纳入了 1280 名明显健康的中国儿童。使用罗氏 Elecsys Troponin T Gen 5 STAT 测定法分析 cTnT 的血清水平。根据临床和实验室标准协会 C28-A3 指南，计算了不同年龄亚组中第 99 百分位上限（URL）的 90%置信区间（CI）。
第 99 百分位 URL 分别为 1 至<4 个月龄为 38（90%CI：37.0-51.0）ng/L，4 至≤12 个月龄为 26（90%CI：25.2-28.5）ng/L，1 至 18 岁为 12（90%CI：11.1-12.9）ng/L。对于 1 至 18 岁的受试者，男孩的 cTnT 水平略高于女孩（P =.003），而我们的检测方法无法测量 50%女孩的低 cTnT 浓度（≥检测限）。
我们的研究提供了罗氏诊断的第 5 代 cTnT 检测在中国儿童中的年龄特异性 URL，这对儿科心脏病学中检测结果的解释和使用具有重要的临床意义。
