Department of Medical Biochemistry, Vestfold Hospital Trust, Tønsberg, Norway.
Kristiania University College, School of Health Sciences, Oslo, Norway.
Scand J Clin Lab Invest. 2021 May;81(3):208-212. doi: 10.1080/00365513.2021.1884893. Epub 2021 Feb 19.
Appropriate reference intervals are important for correct interpretation of laboratory test results. The primary objective of the present study was to establish pediatric reference intervals for biochemical markers essential in the assessment of iron status. As a secondary objective we calculated the prevalence of iron deficiency according to WHO recommendations. Blood samples were obtained from 1355 healthy children 6-12 years of age participating in the Health Oriented Pedagogical Project (HOPP). For our primary objective, data from 1333 children were used to establish reference intervals for ferritin, iron, transferrin and transferrin saturation. Following the CLSI C28-A3 guidelines, the 2.5 and 97.5 percentiles with corresponding 90% confidence intervals, were estimated by the nonparametric method. None of the measured analytes required partitioning for age or sex. The prevalence of iron deficiency was 8.2%, which is higher than reported in other populations.
适当的参考区间对于正确解读实验室检测结果非常重要。本研究的主要目的是为评估铁状态的生化标志物建立儿童参考区间。作为次要目标，我们根据世界卫生组织的建议计算了缺铁的患病率。从参加健康导向教育项目（HOPP）的 1355 名 6-12 岁健康儿童中采集血样。为了实现我们的主要目标，我们使用 1333 名儿童的数据来建立铁蛋白、铁、转铁蛋白和转铁蛋白饱和度的参考区间。根据 CLSI C28-A3 指南，采用非参数法估计了 2.5%和 97.5%分位数及其相应的 90%置信区间。所测量的分析物均无需按年龄或性别进行分区。缺铁的患病率为 8.2%，高于其他人群的报告。
