Department of Ophthalmology, Samsung Changwon Hospital, SungkyunkwanUniversity School of Medicine, Changwon, Korea.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029102.
The objective of this study was to investigate the difference in clinical features according to age and factors affecting recovery of acquired sixth cranial nerve (CN6) palsy.A total of 156 patients with acute CN6 palsy between March 2016 and August 2021 who were followed up for at least 3 months were included in this study. Etiology, rate of recovery, and factors associated with recovery were retrospectively investigated.The average age of patients with CN6 palsy was about 60years and the mean duration of recovery was about 2.5 months. Of 156 patients, 72 (46.15%) had a microvascular etiology and 25 (16.03%) patients had a brain vascular lesions. Brain neoplasm, trauma, and "others" were found in 10 (6.41%), 11 (7.05%), and 15 (9.62%) patients, respectively. Among the total of 156 patients, 28 (17.95%) failed to completely recover. Non-isolated CN6 palsy with other cranial nerve palsies were recorded in 29 (18.59%) cases. Comparison of age (<50years vs ≥50years), between recovery and non-recovery groups showed that etiology was significantly different.The recovery rate of acquired CN6 palsy was about 82% and about 27% of patients had brain lesions. Also, varying rates and duration of recovery were found according to etiology, so we should be pay attention to diagnosis of causative disease in CN6 palsy patients.
本研究旨在探讨年龄和影响获得性第六颅神经（CN6）麻痹恢复的因素对临床特征的影响。
共纳入 156 例 2016 年 3 月至 2021 年 8 月随访至少 3 个月的急性 CN6 麻痹患者，回顾性调查病因、恢复率和与恢复相关的因素。
CN6 麻痹患者的平均年龄约为 60 岁，平均恢复时间约为 2.5 个月。在 156 例患者中，72 例（46.15%）有微血管病因，25 例（16.03%）有脑血管病变。10 例（6.41%）、11 例（7.05%）和 15 例（9.62%）患者分别发现脑肿瘤、创伤和“其他”。在 156 例患者中，28 例（17.95%）未能完全恢复。29 例（18.59%）伴有其他颅神经麻痹的非孤立性 CN6 麻痹。
对年龄（<50 岁与≥50 岁）、恢复组与未恢复组之间的比较表明，病因明显不同。
获得性 CN6 麻痹的恢复率约为 82%，约 27%的患者有脑部病变。此外，根据病因的不同，恢复率和持续时间也不同，因此我们应该注意在 CN6 麻痹患者中诊断病因。
