在海洛因中体验“一英里高”：从“英里高城”（美国科罗拉多州丹佛市的别称）看阿片类药物泛滥的教训。
Mile high on heroin: Lessons on the opioid epidemic from the Mile High City.
机构信息
Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
出版信息
Bioessays. 2022 Jun;44(6):e2100297. doi: 10.1002/bies.202100297. Epub 2022 Mar 31.
Abstract
This commentary discusses the novelty of the preclinical opioid choice model published in Heinsbroek et al., Nat Commun, 2021, and the potential influence of altitude on the reported findings. The studies were performed in the Mile High City of Denver, Colorado, where a unique subpopulation of heroin-choosing rats were noted.
摘要
这篇评论讨论了 Heinsbroek 等人在《自然通讯》上发表的临床前阿片类药物选择模型的新颖性，以及海拔高度对报告结果的潜在影响。这些研究是在科罗拉多州丹佛市进行的，该市是一个独特的海洛因选择大鼠亚群。
相似文献
1
Mile high on heroin: Lessons on the opioid epidemic from the Mile High City.在海洛因中体验“一英里高”：从“英里高城”（美国科罗拉多州丹佛市的别称）看阿片类药物泛滥的教训。
Bioessays. 2022 Jun;44(6):e2100297. doi: 10.1002/bies.202100297. Epub 2022 Mar 31.
2
The opioid epidemic.阿片类药物流行。
Best Pract Res Clin Obstet Gynaecol. 2022 Dec;85(Pt B):53-58. doi: 10.1016/j.bpobgyn.2022.07.003. Epub 2022 Jul 19.
3
In the midst of an opioid epidemic: Pharmacists on the frontline of substance use disorder treatment.在阿片类药物流行之际：药剂师身处物质使用障碍治疗的前线。
Am J Health Syst Pharm. 2021 Feb 8;78(4):277-278. doi: 10.1093/ajhp/zxaa410.
4
Going beyond prescription pain relievers to understand the opioid epidemic: the role of illicit fentanyl, new psychoactive substances, and street heroin.超越处方止痛药，深入了解阿片类药物流行：非法芬太尼、新型精神活性物质和街头海洛因的作用。
Postgrad Med. 2018 Jan;130(1):1-8. doi: 10.1080/00325481.2018.1407618. Epub 2017 Nov 30.
5
Does self-reported consumption of heroin correlate with dose of methadone among pregnant people with opioid use disorder?在患有阿片类药物使用障碍的孕妇中，自我报告的海洛因消费量与美沙酮剂量之间是否存在关联？
Am J Obstet Gynecol MFM. 2022 May;4(3):100587. doi: 10.1016/j.ajogmf.2022.100587. Epub 2022 Feb 3.
6
Modulation of drug choice by extended drug access and withdrawal in rhesus monkeys: Implications for negative reinforcement as a driver of addiction and target for medications development.延长药物获取和戒断对恒河猴药物选择的调制：对作为成瘾驱动因素和药物开发靶点的负性强化的意义。
Pharmacol Biochem Behav. 2018 Jan;164:32-39. doi: 10.1016/j.pbb.2017.04.006. Epub 2017 Apr 22.
7
Opioid Overdose: Risk Assessment and Mitigation in Outpatient Treatment.阿片类药物过量：门诊治疗中的风险评估与缓解
J Addict Med. 2016 Nov/Dec;10(6):382-386. doi: 10.1097/ADM.0000000000000241.
8
A Call to Action to Combat the Opioid Epidemic Among Women.呼吁行动起来，应对女性阿片类药物泛滥问题。
J Addict Med. 2020 Sep/Oct;14(5):364-366. doi: 10.1097/ADM.0000000000000622.
9
Serious Illness and Limitations of Death Certificate-Based Data: Urgent Lessons From the Opioid Epidemic.重病与基于死亡证明数据的局限性：阿片类药物流行的紧急教训
Am J Public Health. 2022 Feb;112(S1):S36-S38. doi: 10.2105/AJPH.2021.306409.
10
Delay discounting in opioid use disorder: Differences between heroin and prescription opioid users.阿片类物质使用障碍中的延迟折扣：海洛因使用者与处方阿片类药物使用者之间的差异。
Drug Alcohol Depend. 2016 Dec 1;169:68-72. doi: 10.1016/j.drugalcdep.2016.10.009. Epub 2016 Oct 17.
引用本文的文献
1
A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.关于影响大鼠药物与非药物选择的行为经济学操纵的综述。
Perspect Behav Sci. 2025 Apr 7;48(2):341-366. doi: 10.1007/s40614-025-00445-5. eCollection 2025 Jun.
2
The psychedelic drug DOI reduces heroin motivation by targeting 5-HT2A receptors in a heroin and alcohol co-use model.迷幻药物 DOI 通过作用于海洛因-酒精共用药理学模型中的 5-HT2A 受体减少海洛因的动机。
Neuropharmacology. 2024 Dec 15;261:110163. doi: 10.1016/j.neuropharm.2024.110163. Epub 2024 Sep 26.
本文引用的文献
1
A common limiter circuit for opioid choice and relapse identified in a rodent addiction model.一种常见的阿片类药物选择和复吸限制电路在啮齿类动物成瘾模型中被发现。
Nat Commun. 2021 Aug 9;12(1):4788. doi: 10.1038/s41467-021-25080-x.
2
NMDA Receptor-Mediated Excitotoxicity Is Involved in Neuronal Apoptosis and Cognitive Impairment Induced by Chronic Hypobaric Hypoxia Exposure at High Altitude.NMDA 受体介导的兴奋性毒性参与了慢性低压缺氧暴露于高海拔地区引起的神经元凋亡和认知障碍。
High Alt Med Biol. 2021 Mar;22(1):45-57. doi: 10.1089/ham.2020.0127. Epub 2020 Nov 27.
3
Opioid analgesic use and its sequelae: Opioid and other substance use disorders.阿片类镇痛药的使用及其后果：阿片类药物和其他物质使用障碍。
Early Interv Psychiatry. 2021 Aug;15(4):975-982. doi: 10.1111/eip.13043. Epub 2020 Sep 15.
4
Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.在可卡因选择过程中，药代动力学胜过药效学：与成瘾的多巴胺假说的调和。
Neuropsychopharmacology. 2021 Jan;46(2):288-296. doi: 10.1038/s41386-020-0786-9. Epub 2020 Jul 30.
5
Baseline cocaine demand predicts contingency management treatment outcomes for cocaine-use disorder.基线可卡因需求预测可卡因使用障碍的应急管理治疗结果。
Psychol Addict Behav. 2020 Feb;34(1):164-174. doi: 10.1037/adb0000475. Epub 2019 Jun 24.
6
Association between altitude, prescription opioid misuse, and fatal overdoses.海拔高度、处方阿片类药物滥用与致命过量用药之间的关联。
Addict Behav Rep. 2019 Feb 18;9:100167. doi: 10.1016/j.abrep.2019.100167. eCollection 2019 Jun.
7
Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in rats.需求弹性可预测成瘾内表型以及大鼠中一种食欲素/下丘脑泌素-1受体拮抗剂的治疗效果。
Eur J Neurosci. 2019 Aug;50(3):2602-2612. doi: 10.1111/ejn.14166. Epub 2018 Oct 14.
8
Novel models of drug relapse and craving after voluntary abstinence.自愿戒断后药物复发和渴望的新模型。
Neuropsychopharmacology. 2019 Jan;44(1):234-235. doi: 10.1038/s41386-018-0196-4.
9
Essential values of cocaine and non-drug alternatives predict the choice between them.可卡因和非药物替代品的基本价值预测了它们之间的选择。
Addict Biol. 2017 Nov;22(6):1501-1514. doi: 10.1111/adb.12450. Epub 2016 Sep 14.
10
Extended heroin access increases heroin choices over a potent nondrug alternative.延长海洛因获取途径会增加人们对强力非毒品替代品的海洛因选择。
Neuropsychopharmacology. 2013 Jun;38(7):1209-20. doi: 10.1038/npp.2013.17. Epub 2013 Jan 15.
Zotero 插件