Li Ming, Li Yuke, Jia Wan-Yuan, Sun Guo-Qing, Gao Fan, Zhao Guo-Xiao, Qiu Yi-Feng, Wang Xi-Cun, Liang Yong-Min, Quan Zheng-Jun
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Department of Chemistry and Centre for Scientific Modeling and Computation, Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Org Lett. 2022 Apr 15;24(14):2738-2743. doi: 10.1021/acs.orglett.2c00835. Epub 2022 Mar 31.
The free radical cyclization reaction is a promising strategy for ring framework formation. Herein, we report a copper-catalyzed tandem radical cyclization strategy for preparing substituted lactam derivatives. This reaction proceeds through a radical coupling approach, which not only allows a wide range of alkenes but also is quite compatible with the primary, secondary, and tertiary radicals. In addition, density functional theory calculations were performed to gain insights into the reaction mechanism.
自由基环化反应是一种很有前景的构建环骨架的策略。在此，我们报道一种用于制备取代内酰胺衍生物的铜催化串联自由基环化策略。该反应通过自由基偶联方法进行，不仅能兼容多种烯烃，而且与伯、仲和叔自由基也相当兼容。此外，还进行了密度泛函理论计算以深入了解反应机理。
