Department of Cardiology, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China.
Second Department of Cardiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
PLoS One. 2022 Mar 31;17(3):e0266265. doi: 10.1371/journal.pone.0266265. eCollection 2022.
The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. However, these results were contradictory and just focused on one or two autoimmune diseases. The present study aims to examine the possible association between rs3746444 polymorphism and the risk of autoimmune diseases.
The studies that evaluated the association between miRNA-499 gene polymorphism and autoimmune diseases were retrieved. Five different genetic models were used to evaluate the association. The random-effects model was used to pool the effect sizes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the associations. Stratification analyses were performed by ethnicity and type of autoimmune diseases. False-positive report probability (FPRP) was performed for determining noteworthy associations.
Seventeen articles (twenty studies) involving 4,376 cases and 4,991 controls were identified and included in our meta-analysis. The pooled ORs of all eligible case-control studies indicated a significant association between miRNA-499 gene polymorphism and autoimmune diseases: (T vs. C: OR = 0.877; 95% CI: 0.774, 0.993; P = 0.039). Stratified analysis indicated a significant association across both Caucasian (TT vs. TC+CC: OR = 0.779; 95% CI: 0.622, 0.976; P = 0.030) and Asian (T vs. C: OR = 0.895; 95% CI: 0.808, 0.992; P = 0.035) populations. There was also a significant association in Behcet's disease, rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis populations.
Our meta-analysis suggested that the miRNA-499 rs3746444 polymorphism was associated with an elevated risk of autoimmune diseases in the overall analysis as well as Caucasian and Asian populations.
已有研究报道 miRNA-499 rs3746444 与多种自身免疫性疾病之间存在关联。然而，这些结果存在矛盾，仅关注一两种自身免疫性疾病。本研究旨在探讨 rs3746444 多态性与自身免疫性疾病风险之间的可能关联。
检索评估 miRNA-499 基因多态性与自身免疫性疾病相关性的研究。采用五种不同的遗传模型来评估关联。使用随机效应模型来汇总效应大小。计算比值比（ORs）和 95%置信区间（CIs）来估计关联。按种族和自身免疫性疾病类型进行分层分析。使用虚假阳性报告概率（FPRP）来确定显著关联。
共纳入了 17 篇文章（20 项研究），涉及 4376 例病例和 4991 例对照，进行了荟萃分析。所有合格病例对照研究的汇总 OR 表明 miRNA-499 基因多态性与自身免疫性疾病之间存在显著关联：（T 对 C：OR = 0.877；95%CI：0.774，0.993；P = 0.039）。分层分析表明，在白人和亚洲人群中均存在显著关联（TT 对 TC+CC：OR = 0.779；95%CI：0.622，0.976；P = 0.030）。在白塞病、类风湿关节炎、系统性红斑狼疮和溃疡性结肠炎人群中也存在显著关联。
本荟萃分析表明，miRNA-499 rs3746444 多态性与总体分析以及白人和亚洲人群中的自身免疫性疾病风险升高相关。
