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拉伦氏综合征患者的局灶性癫痫。

Focal Epilepsy in Individuals with Laron Syndrome.

机构信息

Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel,

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,

出版信息

Horm Res Paediatr. 2022;95(3):286-290. doi: 10.1159/000524350. Epub 2022 Mar 31.

DOI:10.1159/000524350
PMID:35358968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9501736/
Abstract

OBJECTIVE

The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS).

METHODS

Data were retrieved from medical records of a single-center cohort of 75 patients with LS.

RESULTS

We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications.

CONCLUSION

Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.

摘要

目的

本研究旨在描述拉伦综合征（LS）患者的局灶性癫痫。

方法

从单中心队列的 75 名 LS 患者的病历中检索数据。

结果

我们首次描述了 4 例伴有局灶性癫痫和 LS 的患者。其中 2 例经历了癫痫持续状态发作。所有 4 例患者的脑电图检查均显示颞区有发作间期癫痫样放电。3 例患者通过抗癫痫药物治疗达到长期无癫痫发作。

结论

LS 患者可能有发生局灶性癫痫的风险，这种癫痫似乎与儿童时期的低血糖发作无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b72/9501736/e93f1f7a0b9e/hrp-0095-0286-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b72/9501736/e93f1f7a0b9e/hrp-0095-0286-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b72/9501736/e93f1f7a0b9e/hrp-0095-0286-g01.jpg

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