Zhonghua Gan Zang Bing Za Zhi. 2022 Feb 20;30(2):137-146. doi: 10.3760/cma.j.cn501113-20220119-00033.
Intrahepatic cholestasis is a clinical syndrome due to the defect of bile acid synthesis, abnormal bile excretion, and mechanical or functional disturbance of intrahepatic bile flows caused by hepatic parenchymal cell and/or intrahepatic bile duct diseases. It commonly occurs as cholestatic liver diseases, intrahepatic cholestasis of pregnancy, and genetic/metabolic-related cholestatic diseases. In recent years, new information and progress in diagnosis and treatment of intrahepatic cholestatic diseases have been achieved. In order to provide updated clinical reference and guidance for clinicians, we organized experts to compile the Expert Consensus on the Diagnosis and Treatment of Intrahepatic Cholestasis (2021), on the basis of the 2015 edition.
肝内胆汁淤积是一种临床综合征，由肝实质细胞和/或肝内胆管疾病导致胆汁酸合成缺陷、胆汁排泄异常以及肝内胆汁流的机械性或功能性紊乱引起。它通常表现为胆汁淤积性肝病、妊娠期肝内胆汁淤积症以及遗传/代谢相关胆汁淤积性疾病。近年来，肝内胆汁淤积性疾病的诊断和治疗取得了新的信息和进展。为了给临床医生提供最新的临床参考和指导，我们组织专家在2015年版的基础上编写了《肝内胆汁淤积诊断和治疗专家共识（2021年版）》。
