Bukhova V P, Samsonova E S, Galakhova T V, Beliaev D L, Bolotskikh L A
Biull Eksp Biol Med. 1986 Nov;102(11):598-600.
A comparative study of skin allografts was performed in germ-free A/Ola mice kept in boxes and in A/Ola and BALB mice raised in ordinary conditions. Skin graft (of C57B1/6 mice) in A/Ola and BALB mice raised in ordinary conditions was shown to reject 16-21 and 12-18 days after the transplantation, respectively without cyclophosphamide (CP) use. CP application in BALB mice, grown in ordinary conditions, prolonged the lifespan of grafts to 12-29 days. The use of CP in germ-free A/Ola mice prolonged the lifespan of grafts to 19-39 days. In germ-free mice kept in boxes the use of an immunodepressant was not accompanied by infectious complications, while the animals kept in the vivarium often died of infectious diseases.
对饲养在盒中的无菌A/Ola小鼠以及饲养在普通条件下的A/Ola和BALB小鼠进行了皮肤同种异体移植的比较研究。在普通条件下饲养的A/Ola和BALB小鼠中（C57B1/6小鼠的）皮肤移植，在未使用环磷酰胺（CP）的情况下，分别在移植后16 - 21天和12 - 18天出现排斥反应。在普通条件下饲养的BALB小鼠中应用CP，可将移植物的存活时间延长至12 - 29天。在无菌A/Ola小鼠中使用CP可将移植物的存活时间延长至19 - 39天。饲养在盒中的无菌小鼠使用免疫抑制剂未出现感染并发症，而饲养在动物饲养室中的动物常死于传染病。
