Hecquet B, Leroy A, Lefebvre J L, Peyrat J P, Adenis L
Bull Cancer. 1986;73(5):535-41.
The kinetics of intratumoral uptake of cisplatin, carboplatin (CBDCA) and TNO-6 were studied in vitro in fragments of tumors of the head and neck maintained in culture medium under conditions simulating therapeutic conditions of chemo-embolization. Cisplatin and TNO-6 are more rapidly taken up than CBDCA (carboplatin). With each of these compounds, after 24 hours a fraction of the platinum taken up is not irreversibly bound to the tissue. The rate of uptake and the proportion of platinum irreversibly bound depends a great deal on the tumor under study. The characteristics of the diffusion indicate that TNO-6 is better used with chemo-embolization than with systemic injection. The opposite finding is seen with carboplatin. Cisplatin appears to to be about equally well-suited for either method of injection.
在模拟化疗栓塞治疗条件下，将头颈部肿瘤碎片置于培养基中进行体外培养，研究了顺铂、卡铂（CBDCA）和TNO-6在肿瘤内的摄取动力学。顺铂和TNO-6比卡铂（CBDCA）摄取更快。使用这些化合物中的每一种，24小时后摄取的一部分铂并未不可逆地与组织结合。摄取速率和铂不可逆结合的比例在很大程度上取决于所研究的肿瘤。扩散特征表明，TNO-6与化疗栓塞联合使用比全身注射效果更好。卡铂则相反。顺铂似乎同样适合这两种注射方法。
