rs7747752与胆汁酸的相互作用增加妊娠期糖尿病风险：一项巢式病例对照研究。

The rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study.

作者信息

Wang Hui, Li Jing, Leng Junhong, Li Weiqin, Liu Jinnan, Yan Xiaoyan, Yu Zhijie, Hu Gang, Ma Ronald C W, Fang Zhongze, Wang Ying, Yang Xilin

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.

Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China.

出版信息

Front Endocrinol (Lausanne). 2022 Mar 10;13:808956. doi: 10.3389/fendo.2022.808956. eCollection 2022.

DOI:10.3389/fendo.2022.808956

PMID:35360068

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8960111/

Abstract

AIMS

The study aimed to explore additive interactions of rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0.

METHODS

A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk.

RESULTS

The rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk.

CONCLUSIONS

The rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated increasing LPC18:0.

摘要

目的

本研究旨在探讨rs7747752与甘氨脱氧胆酸/脱氧胆酸（GUDCA/DCA）对妊娠期糖尿病（GDM）风险的相加相互作用，以及对GDM风险的交互作用是否通过增加溶血磷脂酰胆碱（LPC）18:0和/或饱和脂肪酸（SFA）16:0介导。

方法

在中国天津组织了一项1:1年龄匹配的研究，该研究嵌套于一个前瞻性孕妇队列（207对）中。采用相加相互作用检验交互效应，同时采用中介分析和索贝尔检验来检验rs7747752与低GUDCA/DCA同时存在时LPC18:0和SFA16:0对GDM风险的中介效应。

结果

rs7747752与GDM相关（P<0.05）。rs7747752的C多态性显著增强了低GUDCA的比值比（OR），从4.04（0.72 - 22.8）增至9.02（1.63 - 49.7），低DCA的OR从1.67（0.68 - 4.11）增至4.24（1.84 - 9.76），两者均有显著的相加相互作用。进一步对LPC18:0进行调整后，rs7747752与低DCA的交互效应减弱，具有显著的中介效应（P = 0.003）。高SFA16:0未介导rs7747752与低DCA/GUDCA对GDM风险的交互作用。