Alanazi Ali, Alqahtani Ahmed, Alfahadi Mohammad, Alduhayan Saleh, Alfadhel Abdulaziz, Alharbi Waleed, Alharthi Raghad, Masuadi Emad, Alhameed Majed, Abulaban Ahmad
Division of Neurology, King Abdulaziz Medical City, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia.
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Epilepsy Behav Rep. 2022 Mar 9;18:100532. doi: 10.1016/j.ebr.2022.100532. eCollection 2022.
Antiseizure medication have been associated with an increasing risk of congenital anomalies. Medical authorities recommend taking folic acid during the pre-conceptional period to reduce the risk of congenital malformations in the newborns of women with epilepsy (WWE). In this cross-sectional study, we aimed to measure the adherence of Saudi WWE to folic acid intake. We included WWE visiting outpatient epilepsy clinics in King Abdulaziz Medical City and King Fahad Medical City in Riyadh between September 2017 and August 2018. By consecutive non-probability sampling, we identified 85 patients who met the inclusion criteria of the study. The data were collected by a self-administrated questionnaire. We found that the mean age of the subjects was 33 ± 7.5 years. One third were university graduates. Eighty percent were aware of the role of folic acid in preventing congenital anomalies, and 63.9% were taking it during the preconceptional period. No association was found between educational level and adherence to folic acid intake. In conclusion, adherence to folic acid intake among Saudi WWE is not optimal. More efforts are needed to increase patient adherence to folic acid intake.
抗癫痫药物与先天性异常风险增加有关。医学权威机构建议在孕前期间服用叶酸，以降低癫痫女性（WWE）新生儿先天性畸形的风险。在这项横断面研究中，我们旨在衡量沙特癫痫女性对叶酸摄入的依从性。我们纳入了2017年9月至2018年8月期间在利雅得阿卜杜勒阿齐兹国王医疗城和法赫德国王医疗城的门诊癫痫诊所就诊的癫痫女性。通过连续非概率抽样，我们确定了85名符合研究纳入标准的患者。数据通过自行填写的问卷收集。我们发现受试者的平均年龄为33±7.5岁。三分之一是大学毕业生。80%的人知道叶酸在预防先天性异常中的作用，63.9%的人在孕前期间服用叶酸。未发现教育水平与叶酸摄入依从性之间存在关联。总之，沙特癫痫女性对叶酸摄入的依从性不理想。需要做出更多努力来提高患者对叶酸摄入的依从性。
