哺乳动物生殖干细胞移植的进展及潜在应用。
Progress in germline stem cell transplantation in mammals and the potential usage.
机构信息
Germline Stem Cells and Microenvironment Lab, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
College of Life Science, Nanjing Agricultural University, Nanjing, 210095, China.
出版信息
Reprod Biol Endocrinol. 2022 Mar 31;20(1):59. doi: 10.1186/s12958-022-00930-5.
Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation. Therefore, GSCs transplantation is a promising technique for fertility recovery in the clinic, protection of rare animals and livestock breeding. Though this novel technique faces tremendous challenges, numerous achievements have been made after several decades' endeavor. This review summarizes the current knowledge of GSCs transplantation and its utilization in mammals, and discusses the application prospect in reproductive medicine and animal science.
生殖干细胞（GSCs）是具有自我更新和分化为功能性配子能力的生殖细胞，能够迁移到其龛位，并在移植后重建受体的生育能力。因此，GSCs 移植是一种很有前途的生育力恢复技术，可用于临床、保护珍稀动物和家畜养殖。尽管这项新技术面临着巨大的挑战，但经过几十年的努力，已经取得了许多成就。本综述总结了 GSCs 移植及其在哺乳动物中的应用的最新知识，并讨论了在生殖医学和动物科学中的应用前景。
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