Ricci Costantino, Dika Emi, Lambertini Martina, Ambrosi Francesca, Chiarucci Federico, Chillotti Stefano, Fiorentino Michelangelo, Fabbri Erich, Tassone Daniela, Veronesi Giulia, Tartari Federico, Corti Barbara
Pathology Unit, Maggiore Hospital, AUSL Bologna, Bologna, Italy; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
Pathol Res Pract. 2022 May;233:153805. doi: 10.1016/j.prp.2022.153805. Epub 2022 Mar 28.
The diagnosis of nodal nevi (NN) is challenging as they mimic melanoma metastases (MM), with a detection rate mostly ranging between 1% and 11% in sentinel lymph node biopsy (SLNB). Herein, we assessed the incidence of NN and the association with the clinical-pathological features of primary melanoma, adopting the updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for SLNB.
All cases of paired melanoma and SLNB were retrospectively evaluated (April 2019-May 2020). Appropriate statistical tests were adopted, with significant variables included in the logistic regression model.
81 patients and a total of 186 lymph nodes (LNs) were included. Eleven patients had only NN and 4 had both NN and MM (18.5%); 29 LNs (15.6%) showed at least one NN and 12 (6.5%) showed more than one NN (a total amount of 43 NN was detected). All NN and none MM stained for p16. NN were associated with age < 60 years (p: 0.042), no ulceration (p: 0.025) and nevus-associated melanoma (NAM) (p: 0.018), with this latter being the only predictor at the logistic regression model (p: 0.022).
The updated EORTC protocol shows a high number of NN and highlights a strong association with NAM.
结节性痣（NN）的诊断具有挑战性，因为它们会模仿黑色素瘤转移灶（MM），在前哨淋巴结活检（SLNB）中的检出率大多在1%至11%之间。在此，我们采用更新后的欧洲癌症研究与治疗组织（EORTC）SLNB方案，评估了NN的发生率及其与原发性黑色素瘤临床病理特征的关联。
对2019年4月至2020年5月期间所有配对的黑色素瘤和SLNB病例进行回顾性评估。采用了适当的统计检验，并将显著变量纳入逻辑回归模型。
共纳入81例患者和186个淋巴结（LN）。11例患者仅有NN，4例患者同时有NN和MM（18.5%）；29个LN（15.6%）显示至少有一个NN，12个（6.5%）显示有多个NN（共检测到43个NN）。所有NN均p16染色阳性，而MM均为阴性。NN与年龄<60岁（p：0.042）、无溃疡（p：0.025）和痣相关黑色素瘤（NAM）（p：0.018）相关，后者是逻辑回归模型中的唯一预测因素（p：0.022）。
更新后的EORTC方案显示NN数量较多，并突出了其与NAM的密切关联。
