Cookson W O, Musk A W, Ryan G
Clin Allergy. 1986 Sep;16(5):425-32. doi: 10.1111/j.1365-2222.1986.tb01977.x.
In 105 subjects taken from a student population and aged between 15 and 30 there was a strong positive association between the presence of the atopic state, defined by skin tests, and a high level of non-specific bronchial responsiveness to methacholine (chi 2 = 10.5, d.f. = 2, P = 0.01). Regression analysis showed a history of asthma, and the symptom of wheeze, to be predominantly predicted by the degree of bronchial responsiveness (R2 = 31%), with only a minor independent contribution from the degree of atopy (R2 a further 5%). The genetic or other reasons for the association between bronchial responsiveness and atopy may have importance in understanding the aetiology of allergic asthma.
在从学生群体中选取的105名年龄在15至30岁之间的受试者中，通过皮肤试验定义的特应性状态与对乙酰甲胆碱的高水平非特异性支气管反应性之间存在强烈的正相关（卡方 = 10.5，自由度 = 2，P = 0.01）。回归分析表明，哮喘病史和喘息症状主要由支气管反应性程度预测（R2 = 31%），而特应性程度的独立贡献较小（R2再增加5%）。支气管反应性与特应性之间关联的遗传或其他原因可能在理解过敏性哮喘的病因方面具有重要意义。
