低密度脂蛋白和血压是透析儿童血管病变的重要危险因素：一项单中心研究。
Low-density lipoprotein and blood pressure are important risk factors for vasculopathy in children on dialysis: A single center study.
机构信息
Department of Pediatric Nephrology, Faculty of Medicine, Ege University, İzmir, Turkey.
Department of Pediatric Cardiology, Faculty of Medicine, Ege University, İzmir, Turkey.
出版信息
Ther Apher Dial. 2022 Dec;26(6):1220-1225. doi: 10.1111/1744-9987.13846. Epub 2022 Apr 19.
INTRODUCTION
We searched for risk factors of cardiovascular assessment among children on dialysis.
METHODS
This is a cross-sectional study of cardiovascular assessment of all patients on dialysis at Ege University Children's Hospital. Pediatric patients between the ages of 6 and 21 who were on HD and peritoneal dialysis treatment were included in the study. Cardiovascular evaluation included left ventricular mass index (LVMI), pulse wave velocity (PWV), and carotid intima-media thickness (cIMT) measurements.
RESULTS
Nineteen patients were included in this study. The LDL had a correlation with the cIMT z-score, but not to PWVz-score. Binary Logistic regression analysis found that only LDL was significantly associated to increased cIMT.
CONCLUSION
This study reports an association between high LDL and high BP increased cIMT on dialyzed children. Strategies to reduce LDL and BP in dialysis patients may prevent vasculopathy and long-term cardiovascular complications.
简介
我们研究了透析儿童心血管评估的危险因素。
方法
这是一项对伊兹密尔大学儿童医院所有透析患者进行心血管评估的横断面研究。本研究纳入了年龄在 6 至 21 岁之间、正在接受血液透析和腹膜透析治疗的儿科患者。心血管评估包括左心室质量指数（LVMI）、脉搏波速度（PWV）和颈动脉内膜中层厚度（cIMT）测量。
结果
本研究纳入了 19 名患者。LDL 与 cIMT z 评分相关，但与 PWVz 评分无关。二元逻辑回归分析发现，只有 LDL 与 cIMT 增加显著相关。
结论
本研究报告了在透析儿童中，高 LDL 和高血压与 cIMT 增加之间存在关联。在透析患者中降低 LDL 和血压的策略可能预防血管病变和长期心血管并发症。
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