Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
Ann Hum Biol. 2022 Mar;49(2):156-163. doi: 10.1080/03014460.2022.2061048. Epub 2022 May 2.
Short tandem repeats (STRs) are important as common genetic markers in forensic identification and population genetics due to their highly polymorphic nature.
To explore genetic polymorphisms of the Chinese Hunan Han population and further dissect genetic relationships among the Hunan Han and other populations from China.
In this study, samples of 394 unrelated healthy individuals from the Chinese Hunan Han population were analysed using 46 autosomal-STRs (A-STRs). Thirteen previously reported populations (6378 individuals) from China were subsequently collected for population genetic analyses based on 23 shared A-STRs.
In the Hunan Han population, a total of 452 alleles were detected in 46 A-STRs with allelic frequencies spanning from 0.0013 to 0.5571. Except for the Penta D locus in linkage disequilibrium, the combined power of discrimination and the combined power of exclusion for 45 A-STRs in the Hunan Han population were 0.999999999999999999999999999999999999999999999999510314 and 0.999999999999999726596, respectively. Results of interpopulation differentiation, principal component analysis, and phylogenetic relationship analyses uniformly showed that the Hunan Han have closer genetic affinities with Han populations from different Chinese regions and a geographically close ethnic minority group, namely the Hubei Tujia.
To summarise, these 46 A-STRs showed high polymorphism in the Chinese Hunan Han population for forensic practice.
短串联重复序列（STRs）因其高度多态性而成为法医鉴定和群体遗传学中常用的遗传标记。
探索中国湖南汉族人群的遗传多态性，并进一步解析湖南汉族人群与中国其他人群的遗传关系。
本研究采用 46 个常染色体 STR（A-STRs）对 394 名无血缘关系的中国湖南汉族健康个体进行分析。随后，根据 23 个共享 A-STRs，收集了来自中国的 13 个先前报道的人群（6378 人）进行群体遗传分析。
在湖南汉族人群中，46 个 A-STR 共检出 452 个等位基因，等位基因频率范围为 0.0013 至 0.5571。除 Penta D 基因座处于连锁不平衡外，45 个 A-STR 在湖南汉族人群中的联合判别力和联合排除力分别为 0.99999999999999999999999999999999999999999999999510314 和 0.999999999999999726596。群体间分化、主成分分析和系统发育关系分析的结果均表明，湖南汉族人群与来自中国不同地区的汉族人群以及地理上相近的少数民族（湖北土家族）具有更密切的遗传关系。
总之，这 46 个 A-STR 在中国湖南汉族人群中具有高度多态性，可用于法医学实践。
