Wesselink P R, Thoden van Velzen S K, Makkes P C
Oral Surg Oral Med Oral Pathol. 1978 May;45(5):789-95. doi: 10.1016/0030-4220(78)90156-1.
The action of endotoxin on subcutaneous connective tissue was examined in an experimental model simulating the dental root canal. The local Shwartzman reaction was used as a tool to detect slight tissue alterations that might otherwise go unobserved. The experimental results warrent, in our opinion, the tentative conclusion that the primary toxicity of endotoxins has no major part in the initiation or maintenance of chronic periapical inflammation.
在模拟牙根管的实验模型中,研究了内毒素对皮下结缔组织的作用。采用局部施瓦茨曼反应作为一种工具,以检测那些可能在其他情况下未被观察到的轻微组织变化。我们认为,实验结果支持这样一个初步结论,即内毒素的主要毒性在慢性根尖周炎的发生或持续过程中不起主要作用。