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预测性因素分析贝叶斯泊松回归模型在潘塞提法治疗马蹄内翻足中的应用。

Factors predictive of Ponseti casting for treating clubfoot: analysis of Bayesian Poisson regression model.

机构信息

Department of Public Health, North South University, Dhaka, Bangladesh.

出版信息

Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):1868-1875. doi: 10.26355/eurrev_202203_28332.

Abstract

OBJECTIVE

Clubfoot is a growing public health concern in Bangladesh, with the incidence of approximately 0.64 to 6.8 in every 1000 live births. For over a decade, Ponseti method has been considered a gold standard for treating the clubfoot. Despite few studies have been estimating the number of casts required to correct the clubfoot deformities by Ponseti method, the subject of interest has always remained. Therefore, this current study aimed to investigate the significant predictive factors for the number of casts required to correct congenital clubfoot.

PATIENTS AND METHODS

In this retrospective cohort study, we used Bayesian Poisson Regression Model to investigate the influencing factors that could predict how many casts are needed to correct the clubfoot. We included 69 patients with 99 affected feet, who completed their corrective phase of treatment in the Ponseti method. For this cohort study, we integrated only pre-tenotomy casting data with no age restrictions. We used Bayesian Poisson regression analysis technique to estimate the predictive factors.

RESULTS

In Bayesian Poisson model, age was the most influencing predictive factor (24.3%) for increasing the number of castings to correct the clubfoot deformity. The clubfoot offspring of the ≤1-year-old was positive, and the incidence rate increased significantly with the casting number. The number of Ponseti casts in male clubfoot children was 28% higher than in female, and this was marginally statistically significant. There was no marked change estimated in the pattern of clubfoot, foot involvement and Pirani score of the severity.

CONCLUSIONS

We concluded that the age factor may influence the number of casts required for the correction of clubfoot and specifically ≤ 1-year-old children are highly impacted. Treating clubfoot at an early age is suggested in this study to increase the success of clubfoot treatment and decrease the risk of relapse.

摘要

目的

在孟加拉国,马蹄足是一个日益严重的公共卫生问题,每 1000 例活产中约有 0.64 至 6.8 例。十多年来,Ponseti 方法一直被认为是治疗马蹄足的金标准。尽管很少有研究估计 Ponseti 方法纠正马蹄足畸形所需的石膏数量,但这一直是研究的热点。因此,本研究旨在探讨影响 Ponseti 方法纠正先天性马蹄足所需石膏数量的显著预测因素。

患者和方法

在这项回顾性队列研究中,我们使用贝叶斯泊松回归模型来研究可能影响预测需要多少石膏来矫正马蹄足的影响因素。我们纳入了 69 名患者的 99 只患足,这些患者在 Ponseti 方法中完成了矫正治疗阶段。对于这个队列研究,我们只整合了没有年龄限制的跟腱切断术前的打石膏数据。我们使用贝叶斯泊松回归分析技术来估计预测因素。

结果

在贝叶斯泊松模型中,年龄是影响增加矫正马蹄足畸形所需石膏数量的最主要的预测因素(24.3%)。1 岁以下的马蹄足患儿呈阳性,发病率随石膏数量的增加而显著升高。男性马蹄足患儿的 Ponseti 石膏数量比女性高 28%,这在统计学上具有边缘显著性。没有明显改变估计的模式的马蹄足,足部受累和严重程度的 Pirani 评分。

结论

我们得出结论,年龄因素可能会影响矫正马蹄足所需的石膏数量,特别是 1 岁以下的儿童受影响最大。本研究建议尽早治疗马蹄足,以提高马蹄足治疗的成功率,降低复发的风险。

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