Department of Pediatric, Division of Neonatology, Dicle University School of Medicine, Diyarbakir, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Mar;26(6):1963-1969. doi: 10.26355/eurrev_202203_28344.
In the neonatal period, diseases such as respiratory distress syndrome, necrotizing enterocolitis, bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular hemorrhage, patent ductus arteriosus hypoxic-ischemic encephalopathy, and hyperbilirubinemia are frequently seen, despite being differently affected by the gestational age. This study aims to examine the relationship between morbidities in the neonatal period and serum vitamin A and vitamin E levels.
In this prospective cohort study, patients who were treated and followed up in the Neonatal Intensive Care Unit between August 2020 and September 2021 were evaluated.
381 patients, 202 male (53%) and 179 female (47%), were included in the study. The mean birth weight was 2642.13±835.91 g (minimum 480 g, maximum 4285 g) and the mean gestational week was 35.3±3.8 (minimum 24 weeks, maximum 42 weeks). The weight of 332 patients (87.2%) was above 1500 g in whom there was a significant increase in respiratory distress, hypoxic-ischemic encephalopathy, and hyperbilirubinemia correlated with a decrease in the vitamin E levels (p=0.001, 0.02, and 0.001, respectively). In infants over 32 weeks of age, there was a significant increase in respiratory distress, hypoxic-ischemic encephalopathy, and hyperbilirubinemia correlated with a decrease in the vitamin E levels (p=0.001, 0.02, and 0.001, respectively). No significant relationship was found between vitamin A levels and neonatal morbidities regardless of the birth weight or gestational age.
We believe that our study may provide convenience to pediatricians and neonatologists in terms of the relationship between vitamin A and E levels and neonatal morbidities in neonates.
在新生儿期，经常会出现呼吸窘迫综合征、坏死性小肠结肠炎、支气管肺发育不良、早产儿视网膜病变、颅内出血、动脉导管未闭、缺氧缺血性脑病和高胆红素血症等疾病，尽管它们受胎龄的影响程度不同。本研究旨在探讨新生儿期疾病与血清维生素 A 和维生素 E 水平之间的关系。
在这项前瞻性队列研究中，评估了 2020 年 8 月至 2021 年 9 月期间在新生儿重症监护病房接受治疗和随访的患者。
本研究共纳入 381 例患者，其中男 202 例（53%），女 179 例（47%）。平均出生体重为 2642.13±835.91g（最低 480g，最高 4285g），平均孕龄为 35.3±3.8 周（最低 24 周，最高 42 周）。在体重超过 1500g 的 332 例患者中，维生素 E 水平的降低与呼吸窘迫、缺氧缺血性脑病和高胆红素血症的发生率显著增加相关（p=0.001、0.02 和 0.001）。在胎龄超过 32 周的婴儿中，维生素 E 水平的降低与呼吸窘迫、缺氧缺血性脑病和高胆红素血症的发生率显著增加相关（p=0.001、0.02 和 0.001）。无论出生体重或胎龄如何，维生素 A 水平与新生儿疾病之间均无显著关系。
我们认为，我们的研究可能为儿科医生和新生儿科医生提供便利，了解维生素 A 和 E 水平与新生儿疾病之间的关系。
