Bouley G, Azoulay-Dupuis E, Gaudebout C
Environ Res. 1986 Dec;41(2):497-504. doi: 10.1016/s0013-9351(86)80144-x.
The natural resistance of nonimmunized C57Bl/6 mice to an intraperitoneal Klebsiella pneumoniae challenge was not significantly affected by prior continuous exposure to 20 ppm NO2 for 4 days. In contrast, the acquired resistance of mice immunized just before and infected just after NO2 exposure was seriously impaired. This could not be explained by the loss of appetite (about 30%) observed in NO2 treated mice, for neither the natural nor acquired resistance of control air exposed mice given approximately 70% ad libitum food and water were significantly modified.
未免疫的C57Bl/6小鼠对腹腔注射肺炎克雷伯菌攻击的天然抵抗力，在事先连续4天暴露于20 ppm二氧化氮的情况下未受到显著影响。相比之下，在二氧化氮暴露之前刚免疫且之后刚感染的小鼠所获得的抵抗力受到严重损害。这无法用在二氧化氮处理的小鼠中观察到的食欲减退（约30%）来解释，因为给予自由采食和饮水约70%的暴露于空气的对照小鼠，其天然抵抗力和获得性抵抗力均未发生显著改变。
