Mercanti D, Luzzatto E, Ciotti M T, Levi G
Exp Cell Res. 1987 Jan;168(1):182-90. doi: 10.1016/0014-4827(87)90427-7.
We have characterized and partially purified a new 'factor' present in human placenta which strongly stimulates the in vitro proliferation of two immunocytochemically characterized subtypes of astrocytes and of bipotential precursors of putative fibrous astrocytes and oligodendrocytes. This 'factor' has an apparent Mr of 60-80 kD and exhibits physicochemical and chromatographic properties characteristic of polypeptides. Our observations suggest that placenta-derived growth factors (PDMF) control the proliferation of glial cells and glial precursors during fetal development.
我们已经鉴定并部分纯化了人胎盘中存在的一种新“因子”，它能强烈刺激两种经免疫细胞化学鉴定的星形胶质细胞亚型以及假定的纤维性星形胶质细胞和少突胶质细胞双能前体细胞的体外增殖。这种“因子”的表观分子量为60 - 80 kD，具有多肽的物理化学和色谱特性。我们的观察结果表明，胎盘衍生生长因子（PDMF）在胎儿发育过程中控制神经胶质细胞和神经胶质前体细胞的增殖。
