Murad Luana Dalbem, Silva Thays de Queiroz, Schilithz Arthur Orlando Corrêa, Fernandes Priscila Valverde, Monteiro Mariana, Murad Leonardo Borges, Fialho Eliane
Nutrition and Dietetics Section, Brazilian National Cancer Institute José Alencar Gomes da Silva (INCA), Rio de Janeiro, RJ, Brazil; Basic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Basic and Experimental Nutrition Department, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Nutr Res. 2022 Jun;102:1-12. doi: 10.1016/j.nutres.2022.02.005. Epub 2022 Feb 25.
Tumor size, inflammation, and nutritional status may be correlated with the immune response to cancer. Our hypothesis is that there is an interrelationship among tumor size, inflammatory response, and body mass index (BMI), and that these variables could alter T-lymphocyte infiltration in patients with laryngeal squamous cell carcinoma (LSCC). A retrospective cohort of 91 surgical LSCC patients treated at a Brazilian National Cancer Reference Center was followed for 5 years. We collected data regarding BMI, clinical factors, patients' lifestyle, C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). Data were obtained in the medical records within a maximum interval of 7 days before surgery. The stromal and intratumoral CD4 and CD8 T-cell infiltrations were obtained by immunohistochemistry. Our results demonstrated a significant correlation among tumor size and BMI, NLR, PLR, and LMR. Similarly, PLR and LMR were significantly correlated with BMI. Tumor size and inflammatory parameters were not associated with changes in T-cell infiltrations. However, patients with low BMIs had a significantly lower density of intratumoral CD4 T lymphocytes infiltrated when compared with normal/high BMI patients (odds ratio, 0.14; 95% confidence interval, 0.03-0.58; P = .007). CD8 T-lymphocyte infiltration did not change in low-BMI patients. In conclusion, we observed a correlation among tumor size, inflammation, and BMI. Tumor size/inflammation axis may be responsible for the change in BMI and, therefore, may have influenced the reduction of intratumoral CD4 T-lymphocyte infiltration in LSCC patients.
肿瘤大小、炎症和营养状况可能与癌症的免疫反应相关。我们的假设是，肿瘤大小、炎症反应和体重指数（BMI）之间存在相互关系，并且这些变量可能会改变喉鳞状细胞癌（LSCC）患者的T淋巴细胞浸润情况。对巴西国家癌症参考中心治疗的91例接受手术的LSCC患者进行了为期5年的回顾性队列研究。我们收集了有关BMI、临床因素、患者生活方式、C反应蛋白、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及淋巴细胞与单核细胞比值（LMR）的数据。数据在术前最多7天的医疗记录中获取。通过免疫组织化学获得基质和肿瘤内CD4和CD8 T细胞浸润情况。我们的结果表明，肿瘤大小与BMI、NLR、PLR和LMR之间存在显著相关性。同样，PLR和LMR与BMI也显著相关。肿瘤大小和炎症参数与T细胞浸润的变化无关。然而，与正常/高BMI患者相比，低BMI患者肿瘤内浸润的CD4 T淋巴细胞密度显著降低（优势比，0.14；95%置信区间，0.03 - 0.58；P = 0.007）。低BMI患者的CD8 T淋巴细胞浸润没有变化。总之，我们观察到肿瘤大小、炎症和BMI之间存在相关性。肿瘤大小/炎症轴可能是BMI变化的原因，因此可能影响了LSCC患者肿瘤内CD4 T淋巴细胞浸润的减少。
