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TREM2 and calcium signaling in microglia - is it relevant for Alzheimer's disease?

作者信息

Gerasimov Evgenii, Pchitskaya Ekaterina, Bezprozvanny Ilya

机构信息

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Khlopina St. 11, 194021,St. Petersburg, Russia.

Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, Khlopina St. 11, 194021,St. Petersburg, Russia; Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, United States of America.

出版信息

Cell Calcium. 2022 Jun;104:102584. doi: 10.1016/j.ceca.2022.102584. Epub 2022 Mar 26.

DOI:10.1016/j.ceca.2022.102584
PMID:35366517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9701094/
Abstract
摘要

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2
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3
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Elucidating the Role of TREM2 in Alzheimer's Disease.阐明 TREM2 在阿尔茨海默病中的作用。
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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.TREM2介导的早期小胶质细胞反应限制了淀粉样斑块的扩散和毒性。
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本文引用的文献

1
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.TREM2 调节人诱导多能干细胞源性小胶质细胞中嘌呤能受体介导的钙信号和运动。
Elife. 2022 Feb 22;11:e73021. doi: 10.7554/eLife.73021.
2
Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.与 TREM2 的差异化相互作用调节小胶质细胞对修饰的 Aβ 物种的摄取。
Glia. 2021 Dec;69(12):2917-2932. doi: 10.1002/glia.24077. Epub 2021 Aug 24.
3
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?阿尔茨海默病中的神经炎症和小胶质细胞激活:我们的路在何方?
Nat Rev Neurol. 2021 Mar;17(3):157-172. doi: 10.1038/s41582-020-00435-y. Epub 2020 Dec 14.
4
Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca Signals in Dendritic Spines to Regulate Working and Associative Memory.Orai1 通道对于调节工作记忆和联想记忆中谷氨酸诱发的钙信号在树突棘中的放大至关重要。
Cell Rep. 2020 Dec 1;33(9):108464. doi: 10.1016/j.celrep.2020.108464.
5
Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease.钙稳态失衡的逆转:治疗阿尔茨海默病的潜在方法。
Curr Alzheimer Res. 2020;17(4):344-354. doi: 10.2174/1567205017666200528162046.
6
The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.TREM2 在阿尔茨海默病和其他神经退行性疾病中的作用。
Lancet Neurol. 2018 Aug;17(8):721-730. doi: 10.1016/S1474-4422(18)30232-1. Epub 2018 Jul 17.
7
P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.P2Y1 受体阻断可使阿尔茨海默病模型中的网络功能障碍和认知功能恢复正常。
J Exp Med. 2018 Jun 4;215(6):1649-1663. doi: 10.1084/jem.20171487. Epub 2018 May 3.
8
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.TREM2缺陷会损害趋化作用以及小胶质细胞对神经元损伤的反应。
EMBO Rep. 2017 Jul;18(7):1186-1198. doi: 10.15252/embr.201743922. Epub 2017 May 8.
9
Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases.炎症、疼痛和神经退行性疾病中的神经肽与小胶质细胞激活
Mediators Inflamm. 2017;2017:5048616. doi: 10.1155/2017/5048616. Epub 2017 Jan 5.
10
Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis.小胶质细胞受体及其在淀粉样β对阿尔茨海默病发病机制反应中的意义。
J Neuroinflammation. 2014 Mar 13;11:48. doi: 10.1186/1742-2094-11-48.