Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Division of Nephrology, Akashi medical Center, 743-33, Yagi, Ohkubo-cho, Akashi, Hyogo, 674-0063, Japan.
BMC Nephrol. 2022 Apr 2;23(1):128. doi: 10.1186/s12882-022-02764-0.
Nephrotic syndrome (NS) results in massive proteinuria and hypoalbuminemia, which are responsible for a compensatory increase in protein synthesis in the liver. Serum cholinesterase (ChE) also increases in NS. However, its clinical value is not fully elucidated.
In this study, 184 patients with NS who underwent kidney biopsy were included. The patients were divided into two groups according to serum ChE levels, as follows: hypercholinesterasemia (HC) and non-hypercholinesterasemia (NHC) groups. The clinical factors were compared between the two groups.
The HC group had significantly more severe proteinuria and higher prevalence of high selective proteinuria than the NHC group. Furthermore, the prevalence of minimal change nephrotic syndrome (MCNS) was significantly higher in the HC group than that in the NHC group. Multivariate analysis revealed that the severity of proteinuria and MCNS were significantly associated with HC.
In this study, HC in NS was associated with the severity of proteinuria and MCNS, and could help clinicians predict the histological diagnosis of NS.
肾病综合征（NS）会导致大量蛋白尿和低白蛋白血症，这会导致肝脏代偿性增加蛋白质合成。血清胆碱酯酶（ChE）在 NS 中也会增加。然而，其临床价值尚未完全阐明。
本研究纳入了 184 例接受肾活检的 NS 患者。根据血清 ChE 水平将患者分为两组：高胆碱酯酶血症（HC）组和非高胆碱酯酶血症（NHC）组。比较两组的临床因素。
HC 组的蛋白尿程度更严重，高选择性蛋白尿的发生率更高。此外，HC 组的微小病变性肾病综合征（MCNS）发生率明显高于 NHC 组。多变量分析显示，蛋白尿的严重程度和 MCNS 与 HC 显著相关。
本研究表明，NS 中的 HC 与蛋白尿的严重程度和 MCNS 有关，有助于临床医生预测 NS 的组织学诊断。
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