Meng Fanping, Yin Xiaojuan, Ma Xuemei, Guo Xiao-Dong, Jin Bo, Li Hanwei
Liver Cirrhosis Diagnosis and Therapy Center, 302 Hospital of PLA, Beijing 100039;
Affiliated Bayi Children's Hospital, Beijing Military Region General Hospital, Beijing 100700;
Biomed Rep. 2013 Mar;1(2):265-268. doi: 10.3892/br.2013.60. Epub 2013 Jan 21.
A variety of laboratory tests are used in the evaluation of hepatic patients. Serum cholinesterase is reduced in liver dysfunction in contrast to other enzymes. The aim of this study was to assess the value of serum cholinesterase in evaluating liver reserve function in cirrhotic patients. A total of 866 cirrhotic patients were divided into three groups according to their Child-Pugh score. Serum cholinesterase of the patients was detected using the enzyme rate method. Simultaneously, serum albumin was detected using the bromocresol green test, while serum plasma prothrombin time was detected using the clotting assay. Using analysis of variance, the value of serum cholinesterase was analyzed in evaluating the liver reserve function of cirrhotic patients in different Child grades. Using correlation analysis, the correction between cholinesterase and albumin and serum plasma prothrombin time was analyzed. Cirrhotic patients were grouped strictly into A, B and C grades, as per the Child-Pugh score. The results showed that cholinesterase tended to significantly decrease in the three grades Child A (5368.04±1657.32 U/l), Child B (2943.06±1212.84 U/l) and Child C (1832.51±710.68 U/l) (F=264.135, P=0.000). In patients with cirrhosis, cholinesterase was positively correlated with albumin and negatively correlated with serum plasma prothrombin time. In the Child A grade, serum cholinesterase was positively correlated with albumin, but negatively correlated with serum plasma prothrombin time. In the Child B grade, serum cholinesterase remained negatively correlated with serum plasma prothrombin time although there was no significant correlation between cholinesterase and albumin. In the Child C grade, serum cholinesterase positively correlated with albumin, but there was no significant correlation between cholinesterase and serum plasma prothrombin time. In conclusion, correlated with the damage severity of liver cells, cholinesterase may respond to liver reserve function.
多种实验室检查用于肝病患者的评估。与其他酶不同，血清胆碱酯酶在肝功能不全时会降低。本研究的目的是评估血清胆碱酯酶在评估肝硬化患者肝脏储备功能中的价值。根据Child-Pugh评分，将866例肝硬化患者分为三组。采用酶速率法检测患者的血清胆碱酯酶。同时，采用溴甲酚绿法检测血清白蛋白，采用凝血试验检测血清凝血酶原时间。采用方差分析，分析血清胆碱酯酶在评估不同Child分级的肝硬化患者肝脏储备功能中的价值。采用相关性分析，分析胆碱酯酶与白蛋白及血清凝血酶原时间之间的相关性。根据Child-Pugh评分，将肝硬化患者严格分为A、B、C三级。结果显示，在Child A（5368.04±1657.32 U/l）、Child B（2943.06±1212.84 U/l）和Child C（1832.51±710.68 U/l）这三个分级中，胆碱酯酶均呈明显下降趋势（F=264.135，P=0.000）。在肝硬化患者中，胆碱酯酶与白蛋白呈正相关，与血清凝血酶原时间呈负相关。在Child A级中，血清胆碱酯酶与白蛋白呈正相关，但与血清凝血酶原时间呈负相关。在Child B级中，尽管胆碱酯酶与白蛋白之间无显著相关性，但血清胆碱酯酶仍与血清凝血酶原时间呈负相关。在Child C级中，血清胆碱酯酶与白蛋白呈正相关，但胆碱酯酶与血清凝血酶原时间之间无显著相关性。总之，胆碱酯酶可能与肝细胞损伤严重程度相关，可反映肝脏储备功能。
