Penn State/ Hershey Medical Center, Department of Dermatology, 500 University Drive, Hershey, PA 17033, USA.
Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.
Dermatol Clin. 2022 Apr;40(2):167-178. doi: 10.1016/j.det.2021.12.004. Epub 2022 Mar 4.
Homeostasis of the cutaneous microenvironment is complex and depends on multiple intrinsic and extrinsic factors, including the influence of hormones. Hormones exert action on the hair follicle and associated sebaceous glands via both endocrine and intracrine mechanisms. The profound impact of hormonal action on follicular homeostasis can be leveraged in the treatment of disorders, such as acne and hidradenitis suppurativa. The clinician must have an intimate knowledge of the rationale for use, mechanism of action, and possible side effects of hormonal therapy when using these agents to treat adolescents with cutaneous disease.
皮肤微环境的稳态非常复杂，取决于多种内在和外在因素，包括激素的影响。激素通过内分泌和胞内机制对毛囊和相关的皮脂腺发挥作用。激素对毛囊稳态的深远影响可用于治疗某些疾病，如痤疮和化脓性汗腺炎。当使用这些药物治疗患有皮肤疾病的青少年时，临床医生必须深入了解激素治疗的使用原理、作用机制和可能的副作用。
