Takebayashi K, Nojima T, Inoue K
Hokkaido Igaku Zasshi. 1986 Sep;61(5):690-5.
Twenty seven cases of rhabdomyosarcoma from pathologic files of the Hokkaido University Hospital from 1975 to 1985 were reviewed and the presence of myoglobin and S-100 protein was investigated immunohistochemically. Their average age at diagnosis was 30.7 years (ranging from two months to 77 years) and there was a predilection for males in a ratio of 1.7:1. The common locations were the head and neck. Nine cases were positively stained for myoglobin, mainly in the cytoplasm of rhabdomyoblasts and 19 cases were positive for S-100 protein and alpha-subunit of S-100 protein in the cytoplasm of immature tumor cells as well as of rhabdomyoblasts. In seven cases, both of myoglobin and S-100 protein were demonstrated. Although S-100 protein is not strictly specific, however, these results suggest that the immunohistochemical demonstration of S-100 protein can be a useful diagnostic tool of rhabdomyosarcoma.
回顾了北海道大学医院1975年至1985年病理档案中的27例横纹肌肉瘤病例，并通过免疫组织化学方法研究了肌红蛋白和S-100蛋白的存在情况。他们诊断时的平均年龄为30.7岁（范围从两个月到77岁），男性更易患病，男女比例为1.7:1。常见部位为头颈部。9例肌红蛋白呈阳性染色，主要在成肌细胞的细胞质中；19例S-100蛋白和S-100蛋白α亚基在未成熟肿瘤细胞以及成肌细胞的细胞质中呈阳性。7例同时显示肌红蛋白和S-100蛋白阳性。尽管S-100蛋白并非严格特异性的，然而，这些结果表明S-100蛋白的免疫组织化学显示可作为横纹肌肉瘤的一种有用诊断工具。
