Lindop G B, Leckie B, Winearls C G
Histopathology. 1986 Oct;10(10):1077-88. doi: 10.1111/j.1365-2559.1986.tb02544.x.
This is a case report of a 14-year-old girl who presented with malignant hypertension. She had high plasma levels of both active and inactive renin and investigation revealed a renal tumour. The tumour, a renal cell carcinoma, was removed by nephrectomy following which the blood pressure and the plasma renin levels fell to normal. An immunocytochemical study using an antibody to pure human renin showed no detectable renin in the kidney but the tumour contained a population of granular cells which showed strong positive staining for immunoreactive renin. We present the clinical, biochemical, histological, immunocytochemical and ultrastructural features of this case as evidence that this was a renin-secreting renal cell carcinoma.
这是一例14岁患有恶性高血压女孩的病例报告。她的血浆中活性肾素和非活性肾素水平均升高，检查发现有一个肾肿瘤。该肿瘤为肾细胞癌，通过肾切除术将其切除，术后血压和血浆肾素水平降至正常。使用抗纯人肾素抗体进行的免疫细胞化学研究显示，肾脏中未检测到肾素，但肿瘤中含有一群颗粒细胞，这些细胞对免疫反应性肾素呈强阳性染色。我们展示了该病例的临床、生化、组织学、免疫细胞化学和超微结构特征，以证明这是一例分泌肾素的肾细胞癌。
