Araj G F, Khattar M A, Thulesius O, Pazhoor A
Int J Clin Pharmacol Ther Toxicol. 1986 Oct;24(10):542-5.
Serum gentamicin levels were assayed in patients receiving the aminoglycoside to determine dosage adjustments. The accuracy and reproducibility of three methods were compared; bioassay, enzyme multiplied immunoassay (Syva EMIT) and fluorescence polarisation immunoassay (Abbott TDx). Each assay method offered acceptable precision. The bioassay method correlated well with both the enzyme multiplied immunoassay and the fluorescence polarisation immunoassay (correlation coefficients 0.854 and 0.937, respectively). The automated methods provide results within 15 min and are not influenced by combinations of antibiotics, hence they are the methods of choice for aminoglycoside determinations.
对接受氨基糖苷类药物治疗的患者测定血清庆大霉素水平，以确定剂量调整。比较了三种方法的准确性和可重复性：生物测定法、酶放大免疫测定法（Syva EMIT）和荧光偏振免疫测定法（Abbott TDx）。每种测定方法都具有可接受的精密度。生物测定法与酶放大免疫测定法和荧光偏振免疫测定法的相关性都很好（相关系数分别为0.854和0.937）。自动化方法可在15分钟内得出结果，且不受抗生素组合的影响，因此它们是测定氨基糖苷类药物的首选方法。
