Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy.
Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy.
Eur J Radiol. 2022 May;150:110250. doi: 10.1016/j.ejrad.2022.110250. Epub 2022 Mar 18.
To investigate the role of CT-texture analysis of liver ablation area to predict local recurrence after HCC ablation.
Patients treated with liver ablation were retrospectively enrolled. CT-texture analysis was performed on the core and borders of ablation area 1-2 months after procedure. Tumors were grouped according to the onset of local recurrence at follow-up (persistence, recurrence-free, short- or long-term recurrence). Differences in texture parameters and which parameters were predictive of recurrence risk were assessed using a Cox regression model.
151 HCCs were treated in 98 patients (72 ± 9 years, 83 men). 68 HCCs reported no disease recurrence, 32 persistent disease, 19 short-term and 32 long-term recurrence. Median follow-up was 280 [IQR: 156-569] days. Venous phase (Ven) (HR 6.07, 1.29-28.6, p =.02) and Ven (HR 2.27, 1.23-4.21, p =.01) of the ablation core were predictive of short-term recurrence. Ven (HR 0.30, 0.11-0.81, p =.02) and Ven (HR 1.06, 1.01-1.11, p =.02) of the core were independent predictors of tumor recurrence (C-index 0.64, CI 0.52-0.76, p =.03). Arterial phase (Art) of ablation border predicted the recurrence risk (HR 3.15, 1.05-9.42, p =.04) and values higher than 3.71 reported an increased recurrence incidence (p =.05). Art (HR 1.14, 1.04-1.24, p =.01), Late (HR 8.69, 1.11-68.23, p =.04), Late (HR 0.9, 0.82-0.99, p =.03), Late (HR 1.01, 1.00-1.02, p <.01) and Late (HR 0.99, 0.99-1.00, p =.02) of ablation border were independent predictors of local recurrence risk (C-index 0.73, CI 0.61-0.86, p <.01).
CT texture analysis of ablation area performed at 1-2 months follow-up could estimate the risk of local recurrence of hepatocellular carcinoma treated by radiofrequency ablation.
探讨 CT 纹理分析在肝癌消融治疗后局部复发预测中的作用。
回顾性纳入接受肝消融治疗的患者。在术后 1-2 个月对消融区域的核心和边界进行 CT 纹理分析。根据随访时局部复发的发生情况（持续、无复发、短期或长期复发）对肿瘤进行分组。使用 Cox 回归模型评估纹理参数的差异以及哪些参数与复发风险相关。
共纳入 98 例患者的 151 个 HCC（72±9 岁，83 名男性）。68 个 HCC 无疾病复发，32 个 HCC 持续存在，19 个 HCC 短期复发，32 个 HCC 长期复发。中位随访时间为 280[IQR：156-569]天。静脉期（Ven）（HR 6.07，1.29-28.6，p=.02）和 Ven（HR 2.27，1.23-4.21，p=.01）的消融核心是短期复发的预测因素。Ven（HR 0.30，0.11-0.81，p=.02）和 Ven（HR 1.06，1.01-1.11，p=.02）是肿瘤复发的独立预测因子（C 指数 0.64，0.52-0.76，p=.03）。消融边界的动脉期（Art）预测了复发风险（HR 3.15，1.05-9.42，p=.04），高于 3.71 的值提示复发发生率增加（p=.05）。Art（HR 1.14，1.04-1.24，p=.01）、晚期（HR 8.69，1.11-68.23，p=.04）、晚期（HR 0.9，0.82-0.99，p=.03）、晚期（HR 1.01，1.00-1.02，p<.01）和晚期（HR 0.99，0.99-1.00，p<.01）是局部复发风险的独立预测因子（C 指数 0.73，0.61-0.86，p<.01）。
射频消融治疗后 1-2 个月进行的消融区域 CT 纹理分析可以评估肝细胞癌局部复发的风险。
