The hybrids of perylene tetracarboxylic acid functionalized multi-walled carbon nanotubes and chitosan for electrochemical chiral sensing of tryptophan enantiomers.

To introduce abundant carboxyl (COOH) groups to the surface of multi-walled carbon nanotubes (MWCNTs) while maintaining the pristine structure of MWCNTs, 3,4,9,10-perylene tetracarboxylic acid (PTCA) was non-covalently grafted to the sidewalls of MWCNTs. The obtained PTCA functionalized MWCNTs (MWCNTs-PTCA) functioned as a scaffold for the further introduction of chitosan (CS) via electrostatic attractions and hydrogen-bonds. The resultant CS/MWCNTs-PTCA could be used for electrochemical chiral sensing of tryptophan (Trp) enantiomers due to the intrinsic chirality of CS and the high electrocatalytic activity of MWCNTs. Under optimized conditions, the Trp enantiomers could be effectively discriminated at the CS/MWCNTs-PTCA modified electrode by differential pulse voltammetry (DPV), demonstrating that the developed CS/MWCNTs-PTCA might be a potential candidate for the construction of electrochemical chiral sensors.