肠道微生物群与阿尔茨海默病的关系：系统评价。
Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review.
机构信息
Universidad Francisco de Vitoria, Madrid, Spain.
Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
出版信息
J Alzheimers Dis. 2022;87(2):519-528. doi: 10.3233/JAD-215224.
BACKGROUND
In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated.
OBJECTIVE
To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer's disease.
METHOD
Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish.
RESULTS
Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.
CONCLUSION
The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
背景
近年来，科学界对肠道微生物群及其与某些疾病（包括神经疾病）之间关系的研究显著增加。这些研究的结果催生了所谓的“肠脑轴”。尽管它对认知障碍的发生和发展有影响，但肠脑轴的定义和证明还很有限。
目的
提供有关肠道微生物群与阿尔茨海默病之间关系的最佳现有科学证据。
方法
对过去 5 年在国内外数据库中以英文和西文发表的信息进行系统和叙述性综述。
结果
选择了八项观察性研究，这些研究在人类中进行，因此适合纳入本综述。
结论
这些研究的结果支持了这样一种假设，即通过肠脑轴，肠道微生物群与认知障碍之间存在关联。然而，目前，关于这一主题的人类研究，特别是临床试验，还存在很大的不足，这使得难以就此问题提出临床建议。
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