Suppr超能文献

帕金森病患者口腔健康的事实与争议:西班牙患者的病例对照研究。

Facts and controversies regarding oral health in Parkinson's disease: A case-control study in Spanish patients.

机构信息

Department of Stomatology II, Faculty of Medicine and Nursery University of the Basque Country (EHU) Barrio Sarriena s/n, 48940. Leioa. Vizcaya. Spain

出版信息

Med Oral Patol Oral Cir Bucal. 2022 Sep 1;27(5):e419-e425. doi: 10.4317/medoral.25348.

Abstract

BACKGROUND

Parkinson's disease (PD) is one of the leading neurological disorders, affecting more than 6 million people worldwide. These patients present motor and non-motor symptoms, including oral pathology. The objective of this research is to determine the oral health of patients diagnosed with PD, in order to stablish a specific preventive oral health programme.

MATERIAL AND METHODS

Case-control study on 104 PD and 106 control patients. The pre-designed clinical protocol included a complete oral examination on general aspects, standardised epidemiological index for caries, periodontal disease and edentulism, analysis of oral hygiene, presence of mucous/ salivary/ functional disorder, and dental treatments.

RESULTS

A higher number of PD patients consumed daily sweets (p<0.004) and antidepressant drugs (p<0.004). Patients with PD practised less interdental hygiene (p<0.023). The mean plaque index was higher in PD (p<0.003). Drooling (p<0.001), xerostomia (p<0.001), hyposialia (p<0.001), dysphagia (p<0.001), hypogeusia/dysgeusia (p<0.025) and chewing difficulty (p<0.006) were more common in PD.

CONCLUSIONS

Oral disorders are frequent in PD. A good knowledge of these alterations will allow us design a specific preventive protocol. Some oral alterations may be a sign of diagnostic alert or progression of PD.

摘要

背景

帕金森病(PD)是一种主要的神经退行性疾病,影响全球超过 600 万人。这些患者表现出运动和非运动症状,包括口腔病理学。本研究旨在确定被诊断为 PD 的患者的口腔健康状况,以便制定具体的预防性口腔健康计划。

材料和方法

对 104 名 PD 患者和 106 名对照患者进行病例对照研究。预先设计的临床方案包括对一般方面进行全面口腔检查、龋病、牙周病和无牙颌的标准化流行病学指数、口腔卫生分析、存在黏膜/唾液/功能障碍以及牙科治疗。

结果

更多的 PD 患者每天食用甜食(p<0.004)和抗抑郁药(p<0.004)。PD 患者进行的牙间清洁较少(p<0.023)。PD 患者的菌斑指数较高(p<0.003)。流涎(p<0.001)、口干(p<0.001)、唾液分泌减少(p<0.001)、吞咽困难(p<0.001)、味觉减退/味觉障碍(p<0.025)和咀嚼困难(p<0.006)在 PD 中更为常见。

结论

口腔疾病在 PD 中很常见。对这些改变的充分了解将使我们能够设计一个特定的预防方案。一些口腔改变可能是 PD 诊断警示或进展的迹象。

相似文献

1
Facts and controversies regarding oral health in Parkinson's disease: A case-control study in Spanish patients.
Med Oral Patol Oral Cir Bucal. 2022 Sep 1;27(5):e419-e425. doi: 10.4317/medoral.25348.
3
SIALORRHEA AND XEROSTOMIA IN PARKINSON'S DISEASE PATIENTS.
Acta Clin Croat. 2022 Aug;61(2):320-326. doi: 10.20471/acc.2022.61.02.19.
4
Dental health of patients with Parkinson's disease in Iceland.
Spec Care Dentist. 2009 May-June;29(3):123-7. doi: 10.1111/j.1754-4505.2009.00075.x.
5
Improvement of oral function and hygiene in Parkinson's disease: A randomised controlled clinical trial.
J Oral Rehabil. 2020 Mar;47(3):370-376. doi: 10.1111/joor.12924. Epub 2020 Jan 5.
6
Orofacial function and oral health in patients with Parkinson's disease.
Eur J Oral Sci. 2011 Feb;119(1):27-32. doi: 10.1111/j.1600-0722.2010.00802.x.
8
Orofacial function and temporomandibular disorders in Parkinson's Disease: a case-controlled study.
BMC Oral Health. 2023 Jun 12;23(1):381. doi: 10.1186/s12903-023-03051-6.
9
Circadian rhythms and influencing factors of xerostomia among Parkinson's disease patients.
Oral Dis. 2019 Jan;25(1):282-289. doi: 10.1111/odi.12942. Epub 2018 Aug 16.
10
Design and development of a novel supportive care product for the treatment of sialorrhea in Parkinson's disease.
Curr Top Med Chem. 2015;15(10):939-54. doi: 10.2174/156802661510150328224130.

引用本文的文献

1
NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology.
Front Neurosci. 2025 May 6;19:1589857. doi: 10.3389/fnins.2025.1589857. eCollection 2025.
2
Oral health implications in Parkinson's disease.
NPJ Parkinsons Dis. 2025 Apr 11;11(1):73. doi: 10.1038/s41531-025-00927-y.
3
Periodontitis: Grade Modifiers Revisited.
Oral Dis. 2025 Jun;31(6):1637-1646. doi: 10.1111/odi.15297. Epub 2025 Feb 27.

本文引用的文献

1
Oral Health Disorders in Parkinson's Disease: More than Meets the Eye.
J Parkinsons Dis. 2021;11(4):1507-1535. doi: 10.3233/JPD-212605.
2
Increased Added Sugar Consumption Is Common in Parkinson's Disease.
Front Nutr. 2021 May 7;8:628845. doi: 10.3389/fnut.2021.628845. eCollection 2021.
3
Tobacco smoking and the risk of Parkinson disease: A 65-year follow-up of 30,000 male British doctors.
Neurology. 2020 May 19;94(20):e2132-e2138. doi: 10.1212/WNL.0000000000009437. Epub 2020 May 5.
4
Parkinson disease.
Eur J Neurol. 2020 Jan;27(1):27-42. doi: 10.1111/ene.14108. Epub 2019 Nov 27.
5
Gastrointestinal Dysfunction in Chinese Patients with Parkinson's Disease.
Parkinsons Dis. 2019 Aug 20;2019:3897315. doi: 10.1155/2019/3897315. eCollection 2019.
6
The Emerging Evidence of the Parkinson Pandemic.
J Parkinsons Dis. 2018;8(s1):S3-S8. doi: 10.3233/JPD-181474.
7
Alcohol consumption and risk for Parkinson's disease: a systematic review and meta-analysis.
J Neurol. 2019 Aug;266(8):1821-1834. doi: 10.1007/s00415-018-9032-3. Epub 2018 Aug 28.
8
Meta-analysis: Risk of dry mouth with second generation antidepressants.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):282-293. doi: 10.1016/j.pnpbp.2017.12.012. Epub 2017 Dec 20.
9
Hyposalivation and xerostomia among Parkinson's disease patients and its impact on quality of life.
Oral Dis. 2017 May;23(4):464-470. doi: 10.1111/odi.12622. Epub 2017 Feb 24.
10
Pathophysiology underlying drooling in Parkinson's disease: oropharyngeal bradykinesia.
Neurol Sci. 2016 Dec;37(12):1987-1991. doi: 10.1007/s10072-016-2708-5. Epub 2016 Sep 9.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验